ArticleHeredity2009
Amphibian sex determination: segregation and linkage analysis using members of the tiger salamander species complex (Ambystoma mexicanum and A. t. tigrinum).
Article in Heredity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Protocol for non-invasive genotyping of axolotls using skin swabbing.STAR protocols · 2026Article
- Larval Pigmentation Reveals Environmental and Genetic Influences in Hybridizing Ambystoma Salamanders.Ecology and evolution · 2025Article
- A brief review of vertebrate sex evolution with a pledge for integrative research: towards 'Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Large-scale variation in single nucleotide polymorphism density within the laboratory axolotl (Ambystoma mexicanum).Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- Review
- Genomic Data Reveal Conserved Female Heterogamety in Giant Salamanders with Gigantic Nuclear Genomes.G3 (Bethesda, Md.) · 2019Article
- Identification of critical sex-biased genes in Andrias davidianus by de novo transcriptome.Molecular genetics and genomics : MGG · 2019Article
- A chromosome-scale assembly of the axolotl genome.Genome research · 2019Article
- Miniscule differences between sex chromosomes in the giant genome of a salamander.Scientific reports · 2018Article
- A linkage map for the Newt Notophthalmus viridescens: Insights in vertebrate genome and chromosome evolution.Developmental biology · 2017Article
- Variation in salamander tail regeneration is associated with genetic factors that determine tail morphology.PloS one · 2013Article
- First-generation linkage map for the common frog Rana temporaria reveals sex-linkage group.Heredity · 2011Article
- Deep divergence and apparent sex-biased dispersal revealed by a Y-linked marker in rainbow trout.Molecular phylogenetics and evolution · 2010Article
- The birds and the bees and the flowers and the trees: lessons from genetic mapping of sex determination in plants and animals.Genetics · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Little is known about the genetic basis of sex determination in vertebrates though considerable progress has been made in recent years. In this study, segregation analysis and linkage mapping were performed to localize an amphibian sex-determining locus (ambysex) in the tiger salamander (Ambystoma) genome. Segregation of sex phenotypes (male and female) among the second generation individuals of interspecific crosses (Ambystoma mexicanum x Ambystoma tigrinum tigrinum) was consistent with Mendelian expectations, although a slight female bias was observed. Individuals from these same crosses were typed for single-nucleotide polymorphisms distributed throughout the genome to identify molecular markers for ambysex. A marker (E24C3) was identified approximately 5.9 cM from ambysex. Linkage of E24C3 to ambysex was independently validated in a second, intraspecific cross (A. mexicanum). Interestingly, ambysex locates to the tip of one of the larger linkage groups of the Ambystoma meiotic map. Considering that this location does not show reduced recombination, we speculate that the ambysex locus may have arisen quite recently, within the last few million years. Localization of ambysex sets the stage for gene identification and provides important tools for studying the effect of sex in laboratory and natural populations of this model amphibian system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.