Evidence map›Paper›PMID 19258539›Full record

ReviewCancer prevention research (Philadelphia, Pa.)2009

Bioactive food components, inflammatory targets, and cancer prevention.

Young S Kim, Matthew R Young, Gerd Bobe, Nancy H Colburn, John A Milner

Open access · bronzeAbstract readReview
In one paragraph

Review in Cancer prevention research (Philadelphia, Pa.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 1 synthesis or guideline pooled it, 133 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. International journal of molecular sciences · 2023
    Article
  9. Review
  10. Effects of Chokeberries (Journal of clinical medicine · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Emodin reduces tumor burden by diminishing M2-like macrophages in colorectal cancer.American journal of physiology. Gastrointestinal and liver physiology · 2022
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Young S KimNutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, Rockville, MD, USA. yk47s@nih.gov
Matthew R Young
Gerd Bobe
Nancy H Colburn
John A Milner
Center for Cancer Research · USNational Cancer Institute · US

Funding

Identification of Biomarkers for Response to Chemoprevention of Colon CancerZIABC011159 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI COLBURN, NANCY H. · 2009 to 2013
$1.3M
Intramural NIH HHS ZIA BC011159
6 · The paper itself

Abstract

Various dietary components may modify chronic inflammatory processes at the stage of cytokine production, amplification of nuclear factor-kappaB-mediated inflammatory gene expression, and the release of anti-inflammatory cytokine, transforming growth factor-beta. This review provides a synopsis of the strengths and weaknesses of the evidence that specific bioactive food components influence inflammation-related targets linked to cancer. A target repeatedly surfacing as a site of action for several dietary components is transforming growth factor beta. Whereas the use of dietary intervention strategies offers intriguing possibilities for maintaining normal cell function by modifying a process that is essential for cancer development and progression, more information is needed to characterize the minimum quantity of the bioactive food components required to bring about a change in inflammation-mediated cancer, the ideal time for intervention, and the importance of genetics in determining the response. Unquestionably, the societal benefits of using foods and their components to prevent chronic inflammation and associated complications, including cancer, are enormous.

Indexed as

DietFoodAnti-Inflammatory AgentsHistone DeacetylasesHumansHydroxyprostaglandin DehydrogenasesInflammationModels, BiologicalNeoplasmsNF-kappa BNutritive ValuePhosphorylationSignal TransductionTransforming Growth Factor beta15-hydroxyprostaglandin dehydrogenaseAnti-Inflammatory AgentsHistone DeacetylasesHydroxyprostaglandin DehydrogenasesNF-kappa BTransforming Growth Factor beta

Identifiers

PMID19258539
PMCPMC3449301
OpenAlexW2159391346

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.