Evidence map›Paper›PMID 19258477›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2009

Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk.

Ellen L Goode, Brooke L Fridley, Robert A Vierkant, Julie M Cunningham, Catherine M Phelan, Stephanie Anderson, David N Rider, Kristin L White, V Shane Pankratz, Honglin Song and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Interaction of CCND2, CDKN1A, and POLD3 Variants in Mexican Patients with Colorectal Cancer.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022
    Article
  5. Combination of genetic variants in cyclin D1 and retinoblastoma genes predict clinical outcome in oral cancer patients.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  6. Oncology letters · 2015
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Global ovarian cancer health disparities.Gynecologic oncology · 2013
    Review
  13. Article
  14. Article
  15. Article
  16. Variation at 8q24 and 9p24 and risk of epithelial ovarian cancer.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2010
    Article
  17. Article
  18. Role of Genetic Variations inCancer genomics & proteomics
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 3 countries.

Ellen L GoodeDepartment of Health Sciences Research, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN 55905, USA. egoode@mayo.edu
Brooke L Fridley
Robert A Vierkant
Julie M Cunningham
Catherine M Phelan
Stephanie Anderson
David N Rider
Kristin L White
V Shane Pankratz
Honglin Song
Estrid Hogdall
Susanne K Kjaer
Alice S Whittemore
Richard DiCioccio
Susan J Ramus
Simon A Gayther
Joellen M Schildkraut
Paul P D Pharaoh
Thomas A Sellers
Mayo Clinic · USDanish Cancer Society · DKMoffitt Cancer Center · USUniversity College London · GBUniversity of Cambridge · GBPiedmont International University · USRoswell Park Comprehensive Cancer Center · USStanford University · US

Funding

The Molecular Epidemiology Of Ovarian CancerR01CA076016 · NCI · DUKE UNIVERSITY · PI SCHILDKRAUT, JOELLEN M. · 1998 to 2010
$6.2M
Genetic Variation in the NF-kappaB Pathway and Ovarian Cancer EtiologyR01CA122443 · NCI · MAYO CLINIC ROCHESTER · PI GOODE, ELLEN L. · 2007 to 2012
$2.7M
Regulation of p53 function by DaxxR01CA088868 · NCI · UNIVERSITY OF PENNSYLVANIA · PI YANG, XIAOLU · 2001 to 2012
$2.6M
Cancer Research UK 10119Cancer Research UK A10119Cancer Research UK C8804/A7058Department of HealthNCI NIH HHS CA016156NCI NIH HHS R01 CA076016NCI NIH HHS R01 CA088868NCI NIH HHS R01 CA122443NCI NIH HHS R01-CA122443NCI NIH HHS R01-CA76016NCI NIH HHS R01-CA88868
6 · The paper itself

Abstract

Polymorphisms in genes critical to cell cycle control are outstanding candidates for association with ovarian cancer risk; numerous genes have been interrogated by multiple research groups using differing tagging single-nucleotide polymorphism (SNP) sets. To maximize information gleaned from existing genotype data, we conducted a combined analysis of five independent studies of invasive epithelial ovarian cancer. Up to 2,120 cases and 3,382 controls were genotyped in the course of two collaborations at a variety of SNPs in 11 cell cycle genes (CDKN2C, CDKN1A, CCND3, CCND1, CCND2, CDKN1B, CDK2, CDK4, RB1, CDKN2D, and CCNE1) and one gene region (CDKN2A-CDKN2B). Because of the semi-overlapping nature of the 123 assayed tagging SNPs, we performed multiple imputation based on fastPHASE using data from White non-Hispanic study participants and participants in the international HapMap Consortium and National Institute of Environmental Health Sciences SNPs Program. Logistic regression assuming a log-additive model was done on combined and imputed data. We observed strengthened signals in imputation-based analyses at several SNPs, particularly CDKN2A-CDKN2B rs3731239; CCND1 rs602652, rs3212879, rs649392, and rs3212891; CDK2 rs2069391, rs2069414, and rs17528736; and CCNE1 rs3218036. These results exemplify the utility of imputation in candidate gene studies and lend evidence to a role of cell cycle genes in ovarian cancer etiology, suggest a reduced set of SNPs to target in additional cases and controls.

Indexed as

AdultAgedAllelesCase-Control StudiesCell CycleCyclin D1Cyclin-Dependent Kinase 2Cyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p16Cyclin EFemaleGenotypeHumansLogistic ModelsMarkov ChainsMiddle AgedCCND1 protein, humanCCNE1 protein, humanCDK2 protein, humanCDKN2B protein, humanCyclin D1Cyclin-Dependent Kinase 2Cyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p16Cyclin EOncogene Proteins

Identifiers

PMID19258477
PMCPMC2743184
OpenAlexW2122028185

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.