ArticleProceedings of the National Academy of Sciences of the United States of America2009
Evidence for liquid water during the high-density to low-density amorphous ice transition.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Guest-Induced Large and Tunable Negative Thermal Expansion in Soft Microporous Carbon.ACS nano · 2026Article
- Exploring the influence of water micro assemblies on protein folding, enzyme catalysis and membrane dynamics.European biophysics journal : EBJ · 2025Review
- Observing growth and interfacial dynamics of nanocrystalline ice in thin amorphous ice films.Nature communications · 2024Article
- CryomicroscopyFaraday discussions · 2022Article
- Following the Crystallization of Amorphous Ice after Ultrafast Laser Heating.The journal of physical chemistry. B · 2022Article
- Direct observation of reversible liquid-liquid transition in a trehalose aqueous solution.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Formation of a Low-Density Liquid Phase during the Dissociation of Gas Hydrates in Confined Environments.Nanomaterials (Basel, Switzerland) · 2021Article
- Experimental evidence of low-density liquid water upon rapid decompression.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Diffusive dynamics during the high-to-low density transition in amorphous ice.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Reduction of lattice disorder in protein crystals by high-pressure cryocooling.Journal of applied crystallography · 2016Article
- Glass-to-cryogenic-liquid transitions in aqueous solutions suggested by crack healing.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- High-resolution X-ray crystal structure of bovine H-protein using the high-pressure cryocooling method.Journal of synchrotron radiation · 2013Article
- Core-softened fluids as a model for water and the hydrophobic effect.The Journal of chemical physics · 2013Article
- A high-pressure cryocooling method for protein crystals and biological samples with reduced background X-ray scatter.Journal of applied crystallography · 2013Article
- Highly compressed two-dimensional form of water at ambient conditions.Scientific reports · 2013Article
- Molecular probe dynamics reveals suppression of ice-like regions in strongly confined supercooled water.PloS one · 2012Article
- Protein dynamical transition at 110 K.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Density hysteresis of heavy water confined in a nanoporous silica matrix.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Microcrystallography, high-pressure cryocooling and BioSAXS at MacCHESS.Journal of synchrotron radiation · 2011Article
- Increasing correlation length in bulk supercooled H2O, D2O, and NaCl solution determined from small angle x-ray scattering.The Journal of chemical physics · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Polymorphism of water has been extensively studied, but controversy still exists over the phase transition between high-density amorphous (HDA) and low-density amorphous (LDA) ice. We report the phase behavior of HDA ice inside high-pressure cryocooled protein crystals. Using X-ray diffraction, we demonstrate that the intermediate states in the temperature range from 80 to 170 K can be reconstructed as a linear combination of HDA and LDA ice, suggesting a first-order transition. We found evidence for a liquid state of water during the ice transition based on the protein crystallographic data. These observations open the possibility that the HDA ice induced by high-pressure cryocooling is a genuine glassy form of high-density liquid.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.