ArticleJournal of cell science2009
KRAB zinc-finger proteins localise to novel KAP1-containing foci that are adjacent to PML nuclear bodies.
Article in Journal of cell science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 1 citations in OpenAlex.
- Daxx and HIRA go viral - How chromatin remodeling complexes affect DNA virus infection.Tumour virus research · 2025Review
- The Multifaceted Roles of Zinc Finger Proteins in Pluripotency and Reprogramming.International journal of molecular sciences · 2025Review
- Article
- Review
- Exploration of nuclear body-enhanced sumoylation reveals that PML represses 2-cell features of embryonic stem cells.Nature communications · 2022Article
- DICER regulates the expression of major satellite repeat transcripts and meiotic chromosome segregation during spermatogenesis.Nucleic acids research · 2020Article
- SIRT6 deacetylates H3K18ac at pericentric chromatin to prevent mitotic errors and cellular senescence.Nature structural & molecular biology · 2016Article
- Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer.Journal of cellular biochemistry · 2015Review
- TRIM28 as a novel transcriptional elongation factor.BMC molecular biology · 2015Review
- KAP1 promotes proliferation and metastatic progression of breast cancer cells.Cancer research · 2015Article
- Comparative ultrastructure of CRM1-Nucleolar bodies (CNoBs), Intranucleolar bodies (INBs) and hybrid PML/p62 bodies uncovers new facets of nuclear body dynamic and diversity.Nucleus (Austin, Tex.) · 2015Article
- Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing.PLoS genetics · 2012Article
- A multiprotein binding interface in an intrinsically disordered region of the tumor suppressor protein interferon regulatory factor-1.The Journal of biological chemistry · 2011Article
- Orphan nuclear bodies.Cold Spring Harbor perspectives in biology · 2010Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The KRAB-zinc finger proteins (KRAB-ZFPs) represent a very large, but poorly understood, family of transcriptional regulators in mammals. They are thought to repress transcription via their interaction with KRAB-associated protein 1 (KAP1), which then assembles a complex of chromatin modifiers to lay down histone marks that are associated with inactive chromatin. Studies of KRAB-ZFP/KAP1-mediated gene silencing, using reporter constructs and ectopically expressed proteins, have shown colocalisation of both KAP1 and repressed reporter target genes to domains of constitutive heterochromatin in the nucleus. However, we show here that although KAP1 does indeed become recruited to pericentric heterochromatin during differentiation of mouse embryonic stem (ES) cells, endogenous KRAB-ZFPs do not. Rather, KRAB-ZFPs and KAP1 relocalise to novel nucleoplasmic foci that we have termed KRAB- and KAP1-associated (KAKA) foci. HP1s can also concentrate in these foci and there is a close spatial relationship between KAKA nuclear foci and PML nuclear bodies. Finally, we reveal differential requirements for the recruitment of KAP1 to pericentric heterochromatin and KAKA foci, and suggest that KAKA foci may contain sumoylated KAP1 - the form of the protein that is active in transcriptional repression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.