ArticleThe Journal of biological chemistry2009
Generation of cubic membranes by controlled homotypic interaction of membrane proteins in the endoplasmic reticulum.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Tissue-selective COPII modulator SEC16B aggravates cardiovascular disease by promoting lipid export.The EMBO journal · 2026Article
- Overproduction of mycotoxin biosynthetic enzymes triggers Fusarium toxisome-shaped structure formation via endoplasmic reticulum remodeling.PLoS pathogens · 2024Article
- RTN4B interacting protein FAM134C promotes ER membrane curvature and has a functional role in autophagy.Molecular biology of the cell · 2021Article
- IntEResting structures: formation and applications of organized smooth endoplasmic reticulum in plant cells.Plant physiology · 2021Article
- The hypothetical role of phosphatidic acid in subverting ER membranes during SARS-CoV infection.Traffic (Copenhagen, Denmark) · 2020Article
- ESCRT machinery mediates selective microautophagy of endoplasmic reticulum in yeast.The EMBO journal · 2020Article
- UPRScience advances · 2020Article
- Cubic membrane formation supports cell survival of amoeba Chaos under starvation-induced stress.Protoplasma · 2018Article
- Mouse Stbd1 isJournal of cell science · 2017Article
- NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology.Scientific reports · 2016Article
- Building Spatial Synthetic Biology with Compartments, Scaffolds, and Communities.Cold Spring Harbor perspectives in biology · 2016Review
- Proliferation and Morphogenesis of the Endoplasmic Reticulum Driven by the Membrane Domain of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Plant Cells.Plant physiology · 2015Article
- ER-phagy mediates selective degradation of endoplasmic reticulum independently of the core autophagy machinery.Journal of cell science · 2014Article
- Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and webs.The Journal of cell biology · 2014Article
- Arresting a Torsin ATPase reshapes the endoplasmic reticulum.The Journal of biological chemistry · 2014Article
- Birbeck granule-like "organized smooth endoplasmic reticulum" resulting from the expression of a cytoplasmic YFP-tagged langerin.PloS one · 2013Article
- A variable cytoplasmic domain segment is necessary for γ-protocadherin trafficking and tubulation in the endosome/lysosome pathway.Molecular biology of the cell · 2011Article
- The relationship between different spectral forms of the protochlorophyllide oxidoreductase complex and the structural organisation of prolamellar bodies isolated from Zea mays.Photosynthesis research · 2011Article
- Alpha-COPI coatomer protein is required for rough endoplasmic reticulum whorl formation in mosquito midgut epithelial cells.PloS one · 2011Article
- Palmitoylation regulates raft affinity for the majority of integral raft proteins.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cell membranes predominantly consist of lamellar lipid bilayers. When studied in vitro, however, many membrane lipids can exhibit non-lamellar morphologies, often with cubic symmetries. An open issue is how lipid polymorphisms influence organelle and cell shape. Here, we used controlled dimerization of artificial membrane proteins in mammalian tissue culture cells to induce an expansion of the endoplasmic reticulum (ER) with cubic symmetry. Although this observation emphasizes ER architectural plasticity, we found that the changed ER membrane became sequestered into large autophagic vacuoles, positive for the autophagy protein LC3. Autophagy may be targeting irregular membrane shapes and/or aggregated protein. We suggest that membrane morphology can be controlled in cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.