ArticleThe Journal of biological chemistry2009
Unfractionated heparin and new heparin analogues from ascidians (chordate-tunicate) ameliorate colitis in rats.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- Sea Cucumber and Blueberry Extracts Suppress Inflammation and Reduce Acute Lung Injury through the Regulation of NF-κB/MAPK/JNK Signaling Pathway in Lipopolysaccharide-Treated C57BL/6 Mice.Molecules (Basel, Switzerland) · 2024Article
- Tunicates as Sources of High-Quality Nutrients and Bioactive Compounds for Food/Feed and Pharmaceutical Applications: A Review.Foods (Basel, Switzerland) · 2023Review
- Antioxidant and Anti-inflammatory Extracts From Sea Cucumbers and Tunicates Induce a Pro-osteogenic Effect in Zebrafish Larvae.Frontiers in nutrition · 2022Article
- Oceans as a Source of Immunotherapy.Marine drugs · 2019Review
- Leishmaniasis and glycosaminoglycans: a future therapeutic strategy?Parasites & vectors · 2018Review
- Marine Carbohydrate-Based Compounds with Medicinal Properties.Marine drugs · 2018Review
- Mesenteric injection of adipose-derived mesenchymal stem cells relieves experimentally-induced colitis in rats by regulating Th17/Treg cell balance.American journal of translational research · 2018Article
- Metabolite profiling of ascidian Styela plicata using LC-MS with multivariate statistical analysis and their antitumor activity.Journal of enzyme inhibition and medicinal chemistry · 2017Article
- The role of heparins and nano-heparins as therapeutic tool in breast cancer.Glycoconjugate journal · 2017Review
- Natural Products Diversity of Marine Ascidians (Tunicates; Ascidiacea) and Successful Drugs in Clinical Development.Natural products and bioprospecting · 2017Review
- Sea Cucumbers Metabolites as Potent Anti-Cancer Agents.Marine drugs · 2015Review
- The effects of marine carbohydrates and glycosylated compounds on human health.International journal of molecular sciences · 2015Review
- Orally Administered Enoxaparin Ameliorates Acute Colitis by Reducing Macrophage-Associated Inflammatory Responses.PloS one · 2015Article
- Methodologies to generate, extract, purify and fractionate yeast ECM for analytical use in proteomics and glycomics.BMC microbiology · 2014Article
- Applications of mass spectrometry to structural analysis of marine oligosaccharides.Marine drugs · 2014Review
- Glycosaminoglycans analogs from marine invertebrates: structure, biological effects, and potential as new therapeutics.Frontiers in cellular and infection microbiology · 2014Review
- Anticancer and cancer preventive properties of marine polysaccharides: some results and prospects.Marine drugs · 2013Article
- Review
- Article
- Enoxaparin improves the course of dextran sodium sulfate-induced colitis in syndecan-1-deficient mice.The American journal of pathology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anti-inflammatory effect of mammalian heparin analogues, named dermatan sulfate and heparin, isolated from the ascidian Styela plicata was accessed in a TNBS-induced colitis model in rats. Subcutaneous administration of the invertebrate compounds during a 7-day period drastically reduced inflammation as observed by the normalization of the macroscopic and histological characteristics of the colon. At the molecular level, a decrease in the production of TNF-alpha, TGF-beta, and VEGF was observed, as well as a reduction of NF-kappaB and MAPK kinase activation. At the cellular level, the heparin analogues attenuated lymphocyte and macrophage recruitment and epithelial cell apoptosis. A drastic reduction in collagen-mediated fibrosis was also observed. No hemorrhagic events were observed after glycan treatment. These results strongly indicate the potential therapeutic use of these compounds for the treatment of colonic inflammation with a lower risk of hemorrhage when compared with mammalian heparin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.