Evidence map›Paper›PMID 19257847›Full record

ReviewFuture microbiology2009

Understanding the regulation of Group B Streptococcal virulence factors.

Lakshmi Rajagopal

Open access · greenAbstract readReview
In one paragraph

Review in Future microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed
8.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 219 citations in OpenAlex.

  1. Group BAJP reports · 2026
    Article
  2. Vaginal Colonization byInfection and drug resistance · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Characterization of Virulence Factors and Antimicrobial Susceptibility ofAnimals : an open access journal from MDPI · 2024
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Lakshmi RajagopalDepartment of Pediatric Infectious Diseases, University of Washington & Seattle Children's Hospital Research Institute, 1900 Ninth Avenue, Seattle, WA 98101-91304, USA. lakshmi.rajagopal@seattlechildrens.org
Seattle Children's Hospital · US

Funding

Eukaryotic-type signaling mediates two-component regulation of GBS virulenceR01AI070749 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI RAJAGOPAL, LAKSHMI · 2007 to 2011
$2.0M
NIAID NIH HHS R01 AI070749PHS HHS R01A1070749
6 · The paper itself

Abstract

Bacterial infections remain a significant threat to the health of newborns and adults. Group B Streptococci (GBS) are Gram-positive bacteria that are common asymptomatic colonizers of healthy adults. However, this opportunistic organism can also subvert suboptimal host defenses to cause severe invasive disease and tissue damage. The increasing emergence of antibiotic-resistant GBS raises more concerns for sustained measures in treatment of the disease. A number of factors that are important for virulence of GBS have been identified. This review summarizes the functions of some well-characterized virulence factors, with an emphasis on how GBS regulates their expression. Regulatory and signaling molecules are attractive drug targets in the treatment of bacterial infections. Consequently, understanding signaling responses of GBS is essential for elucidation of pathogenesis of GBS infection and for the identification of novel therapeutic agents.

Indexed as

Gene Expression Regulation, BacterialHumansSignal TransductionStreptococcal InfectionsStreptococcus agalactiaeVirulence FactorsVirulence Factors

Identifiers

PMID19257847
PMCPMC2691590
OpenAlexW2127621667

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.