ArticleCancer causes & control : CCC2009
Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokers.
Article in Cancer causes & control : CCC, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 5 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- Association of saturated fatty acids with cancer risk: a systematic review and meta-analysis.Lipids in health and disease · 2024Pooled it
- N-6 Polyunsaturated Fatty Acids and Risk of Cancer: Accumulating Evidence from Prospective Studies.Nutrients · 2020Pooled it
- Association of Dietary Intake Ratio of n-3/n-6 Polyunsaturated Fatty Acids with Breast Cancer Risk in Western and Asian Countries: A Meta-AnalysisAsian Pacific journal of cancer prevention : APJCP · 2019Pooled it
- Linoleic acid and breast cancer risk: a meta-analysis.Public health nutrition · 2016Pooled it
- Ratio of n-3/n-6 PUFAs and risk of breast cancer: a meta-analysis of 274135 adult females from 11 independent prospective studies.BMC cancer · 2014Pooled it
- Serum Saturated Fatty Acids including Very Long-Chain Saturated Fatty Acids and Colorectal Cancer Risk among Chinese Population.Nutrients · 2023Article
- A Prospective Analysis of Plasma Phospholipid Fatty Acids and Breast Cancer Risk in 2 Provinces in Canada.Current developments in nutrition · 2021Article
- Article
- Erythrocyte membrane fatty acids and breast cancer risk by tumor tissue expression of immuno-inflammatory markers and fatty acid synthase: a nested case-control study.Breast cancer research : BCR · 2020Article
- Erythrocyte membrane fatty acids and breast cancer risk: a prospective analysis in the nurses' health study II.International journal of cancer · 2018Article
- Article
- Carcinogenesis alters fatty acid profile in breast tissue.Molecular and cellular biochemistry · 2013Article
- Dietary intake of specific fatty acids and breast cancer risk among postmenopausal women in the VITAL cohort.Nutrition and cancer · 2012Article
- Dietary polyunsaturated fatty acids and breast cancer risk in Chinese women: a prospective cohort study.International journal of cancer · 2011Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo examine the association between breast cancer risk and the fatty acid composition of phospholipids in prediagnostic serum samples.
methodsWe analyzed the fatty acid composition in 130 incident postmenopausal breast cancer cases and 257 matched controls nested within the beta-Carotene and Retinol Efficacy Trial Cohort. The fatty acid composition was measured by gas chromatography. Multivariate-adjusted odds ratios and corresponding 95% confidence intervals for the risk of breast cancer were estimated using logistic regression. Stratified analysis was conducted by smoking status.
resultsThere were no associations with breast cancer risk for total saturated, monounsaturated, n-3, n-6, or trans fatty acids among all women. For individual fatty acids, we observed an inverse association with the trans linoleic acid, 18:2n6tt (p(trend)=0.0002). Among current smokers, long-chain saturated fatty acids (22:0 and 24:0) and total 16:1 trans fatty acids were positively associated with the risk of breast cancer, whereas these fatty acids showed no association among former smokers.
conclusionOverall, we observed no significant association between serum phospholipid fatty acids and breast cancer risk, except for the trans linoleic acid isomer 18:2n6tt, which was unexpected. Our finding of a positive association of long-chain saturated fatty acids (22:0 and 24:0) and total 16:1 trans fatty acids with the risk of breast cancer only in current smokers may suggest an effect modification by smoking status. Our findings need to be replicated in future epidemiologic studies.
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