ArticleParasitology research2009
Expression of interferon gamma and proinflammatory cytokines in the cecal mucosa of rats experimentally infected with Blastocystis sp. strain RN94-9.
Article in Parasitology research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 51 citations in OpenAlex.
- Assessment of Lactobacillus acidophilus (L. acidophilus) therapeutic and prophylactic role in rats experimentally infected with Blastocystis subtype 3 (ST3).Parasitology research · 2025Article
- Fatal coinfection of blastocystosis and intestinal trichomoniasis in a rhesus macaque (Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Extracellular Cysteine Proteases of Key Intestinal Protozoan Pathogens-Factors Linked to Virulence and Pathogenicity.International journal of molecular sciences · 2023Review
- Experimental colonization with Blastocystis ST4 is associated with protective immune responses and modulation of gut microbiome in a DSS-induced colitis mouse model.Cellular and molecular life sciences : CMLS · 2022Article
- Influence ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Exosomes secreted byFrontiers in medicine · 2022Article
- Intestinal immune responses to commensal and pathogenic protozoa.Frontiers in immunology · 2022Review
- Metabolic Fluctuations in the Human Stool Obtained fromMetabolites · 2021Article
- Association of Blastocystis ST6 with higher protease activity among symptomatic subjects.BMC microbiology · 2021Article
- New insights into the interactions between Blastocystis, the gut microbiota, and host immunity.PLoS pathogens · 2021Review
- Article
- Intestinal protozoan and helminthic infections among hemodialysis and cancer patients.Parasitology research · 2020Article
- Molecular identification and subtyping of Blastocystis sp. in laboratory rats in China.Parasite (Paris, France) · 2020Article
- Successful Genetic Transfection of the Colonic Protistan Parasite Blastocystis for Reliable Expression of Ectopic Genes.Scientific reports · 2019Article
- Article
- Immunopathological assessments of human Blastocystis spp. in experimentally infected immunocompetent and immunosuppresed mice.Parasitology research · 2016Article
- Ex Vivo and In Vivo Mice Models to Study Blastocystis spp. Adhesion, Colonization and Pathology: Closer to Proving Koch's Postulates.PloS one · 2016Article
- PATHOGENICITY OF Blastocystis sp. TO THE GASTROINTESTINAL TRACT OF MICE: RELATIONSHIP BETWEEN INOCULUM SIZE AND PERIOD OF INFECTION.Revista do Instituto de Medicina Tropical de Sao Paulo · 2015Article
- Differential regulation of proinflammatory cytokine expression by mitogen-activated protein kinases in macrophages in response to intestinal parasite infection.Infection and immunity · 2014Article
- Blastocystis tropism in the pig intestine.Parasitology research · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blastocystis hominis is a zoonotic intestinal protozoan parasite whose pathogenic potential is still controversial. The aim of the present study was to clarify the pathogenicity of Blastocystis parasites in rats. Oral inoculation with 1 x 10(5) cysts of Blastocystis sp. strain RN94-9 in rats resulted in chronic infection in the cecum at least until 4 weeks after infection. Histological examination revealed neither mucosal sloughing nor inflammatory cell infiltration but showed a slight but significant increase in goblet cell numbers in the cecal mucosa 1-3 weeks post-infection. Differential staining of acidic and neutral mucins by the alcian blue-periodic acid-Schiff method showed that the predominantly increased cells were neutral mucin(+) but not acidic mucin(+) goblet cells. Reverse transcription real-time polymerase chain reaction studies demonstrated significant upregulation of the expression of interferon-gamma, interleukin (IL)-12, and tumor necrosis factor alpha, but not IL-6 or granulocyte-macrophage colony-stimulating factor, in the cecal mucosa at 2 and/or 3 weeks post-infection. The induction of local host responses, including mild goblet cell hyperplasia, and significant upregulation of type-1 and proinflammatory cytokines, suggest that Blastocystis sp. strain RN94-9 is a weakly pathogenic organism that could elicit proinflammatory as well as protective responses in local tissues.
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