ArticleImmunogenetics2009
Cost-effective HLA typing with tagging SNPs predicts celiac disease risk haplotypes in the Finnish, Hungarian, and Italian populations.
Article in Immunogenetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Long-term health outcomes of people without celiac disease avoiding gluten consumption: a 25-year prospective cohort study.European journal of clinical nutrition · 2025Article
- Celiac Disease-Narrative Review on Progress in Celiac Disease.Foods (Basel, Switzerland) · 2025Review
- TagSNP approach for HLA risk allele genotyping of Saudi celiac disease patients: effectiveness and pitfalls.Bioscience reports · 2021Article
- Two tagging single-nucleotide polymorphisms to capture HLA-DRB1*07:01-DQA1*02:01-DQB1*02:02 haplotype associated with asparaginase hypersensitivity.British journal of clinical pharmacology · 2021Article
- Independent and cumulative coeliac disease-susceptibility loci are associated with distinct disease phenotypes.Journal of human genetics · 2021Article
- Influence of HLA-DQ2.5 Dose on Clinical Picture of Unrelated Celiac Disease Patients.Nutrients · 2020Article
- First-degree Relatives of Celiac Disease Patients Have Increased Seroreactivity to Serum Microbial Markers.Nutrients · 2020Article
- Cross-ethnicity tagging SNPs for HLA alleles associated with adverse drug reaction.The pharmacogenomics journal · 2019Article
- HLA Haplotype Association with Celiac Disease in Albanian Pediatric Patients from Kosovo.Gastroenterology research and practice · 2019Article
- Small-intestinal TG2-specific plasma cells at different stages of coeliac disease.BMC immunology · 2018Article
- Search for DQ2.5 and DQ8 alleles using a lower cost technique in patients with type 1 diabetes and celiac disease in a population of southern Brazil.Archives of endocrinology and metabolism · 2017Article
- The incidence of HLA-DQ2/DQ8 in Turkish children with celiac disease and a comparison of the geographical distribution of HLA-DQ.Przeglad gastroenterologiczny · 2017Article
- Appropriate clinical use of human leukocyte antigen typing for coeliac disease: an Australasian perspective.Internal medicine journal · 2015Article
- Allele and haplotype frequencies for HLA-DQ in Iranian celiac disease patients.World journal of gastroenterology · 2014Article
- Ex-vivo whole blood secretion of interferon (IFN)-γ and IFN-γ-inducible protein-10 measured by enzyme-linked immunosorbent assay are as sensitive as IFN-γ enzyme-linked immunospot for the detection of gluten-reactive T cells in human leucocyte antigen (HLA)-DQ2·5(+) -associated coeliac disease.Clinical and experimental immunology · 2014Article
- A novel serogenetic approach determines the community prevalence of celiac disease and informs improved diagnostic pathways.BMC medicine · 2013Article
- Article
- Interrogating the major histocompatibility complex with high-throughput genomics.Human molecular genetics · 2012Review
- Origin of celiac disease: how old are predisposing haplotypes?World journal of gastroenterology · 2012Article
- CD14 polymorphisms correlate with an augmented risk for celiac disease in Italian patients.Genes and immunity · 2012Article
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human leukocyte antigen (HLA) genes, located on chromosome 6p21.3, have a crucial role in susceptibility to various autoimmune and inflammatory diseases, such as celiac disease and type 1 diabetes. Certain HLA heterodimers, namely DQ2 (encoded by the DQA1*05 and DQB1*02 alleles) and DQ8 (DQA1*03 and DQB1*0302), are necessary for the development of celiac disease. Traditional genotyping of HLA genes is laborious, time-consuming, and expensive. A novel HLA-genotyping method, using six HLA-tagging single-nucleotide polymorphisms (SNPs) and suitable for high-throughput approaches, was described recently. Our aim was to validate this method in the Finnish, Hungarian, and Italian populations. The six previously reported HLA-tagging SNPs were genotyped in patients with celiac disease and in healthy individuals from Finland, Hungary, and two distinct regions of Italy. The potential of this method was evaluated in analyzing how well the tag SNP results correlate with the HLA genotypes previously determined using traditional HLA-typing methods. Using the tagging SNP method, it is possible to determine the celiac disease risk haplotypes accurately in Finnish, Hungarian, and Italian populations, with specificity and sensitivity ranging from 95% to 100%. In addition, it predicts homozygosity and heterozygosity for a risk haplotype, allowing studies on genotypic risk effects. The method is transferable between populations and therefore suited for large-scale research studies and screening of celiac disease among high-risk individuals or at the population level.
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