ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2009
feG-COOH blunts eosinophilic airway inflammation in a feline model of allergic asthma.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Animal models of asthma: utility and limitations.Journal of asthma and allergy · 2017Review
- Calcium-binding protein, spermatid-specific 1 is expressed in human salivary glands and contains an anti-inflammatory motif.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Salivary gland derived peptides as a new class of anti-inflammatory agents: review of preclinical pharmacology of C-terminal peptides of SMR1 protein.Journal of inflammation (London, England) · 2010Article
- Feline asthma: what's new and where might clinical practice be heading?Journal of feline medicine and surgery · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designThis study investigated if feG-COOH would decrease allergen-induced airway inflammation. MATERIALS OR SUBJECTS: Seven adult cats sensitised to Bermuda grass allergen (BGA) to induce an asthmatic phenotype. TREATMENT: Cats were randomized to receive either feG-COOH (1 mg/kg, PO) or placebo (saline 1 ml, PO) immediately prior to BGA aerosol challenge in a cross-over design.
methodsBronchoalveolar lavage fluid (BALF) was collected and airway inflammatory response assessed via inflammatory cell number and type; IL-4, IFN-gamma and nitric oxide metabolite concentrations. A paired t test was used to compare parameters with a P < 0.05 considered significant.
resultsThe BALF eosinophil percentage was significantly lower in asthmatic cats treated with feG compared with placebo (placebo, 35.3 +/- 12.2%; feG, 22.4 +/- 8.6%; P = 0.002). Treatment with feG did not result in a significant change in any other parameter measured.
conclusionsThese data indicate that a single dose of feG-COOH partially attenuates eosinophilic airway inflammation in experimental feline asthma.
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Registered trials
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