ArticleProceedings of the National Academy of Sciences of the United States of America2009
Instant immunity through chemically programmable vaccination and covalent self-assembly.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Antibody-recruiting molecules: an emerging paradigm for engaging immune function in treating human disease.ACS chemical biology · 2012Pooled it
- Induction of Endogenous Antibody Recruitment to the Surface of the PathogenACS infectious diseases · 2021Article
- Fc-binding antibody-recruiting molecules exploit endogenous antibodies for anti-tumor immune responses.Chemical science · 2020Article
- Re-engineering the Immune Response to Metastatic Cancer: Antibody-Recruiting Small Molecules Targeting the Urokinase Receptor.Angewandte Chemie (International ed. in English) · 2016Article
- N-Sulfonyl-β-lactam hapten as an effective labeling reagent for aldolase mAb.Bioorganic & medicinal chemistry letters · 2015Article
- Rhamnose glycoconjugates for the recruitment of endogenous anti-carbohydrate antibodies to tumor cells.Chembiochem : a European journal of chemical biology · 2014Article
- Chemically programmed antibodies.Trends in biotechnology · 2014Review
- In vitro and in vivo application of anti-cotinine antibody and cotinine-conjugated compounds.BMB reports · 2014Review
- Preparation and activities of macromolecule conjugates of the CCR5 antagonist Maraviroc.ACS medicinal chemistry letters · 2014Article
- Exploring binding and effector functions of natural human antibodies using synthetic immunomodulators.ACS chemical biology · 2013Article
- Covalent modification of cell surfaces with TLR agonists improves & directs immune stimulation.Chemical communications (Cambridge, England) · 2013Article
- Effective molarityIsrael journal of chemistry · 2013Article
- Chemically Programmed Antibodies AS HIV-1 Attachment Inhibitors.ACS medicinal chemistry letters · 2013Article
- A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase.Chembiochem : a European journal of chemical biology · 2012Article
- Reprogramming urokinase into an antibody-recruiting anticancer agent.ACS chemical biology · 2012Article
- Antibodies in infectious diseases: polyclonals, monoclonals and niche biotechnology.New biotechnology · 2011Review
- Supramolecular complexing of membane Siglec CD22 mediated by a polyvalent heterobifunctional ligand that templates on IgM.Bioconjugate chemistry · 2011Article
- The legumain protease-activated auristatin prodrugs suppress tumor growth and metastasis without toxicity.ChemMedChem · 2011Article
- A biosynthetic strategy for re-engineering the Staphylococcus aureus cell wall with non-native small molecules.ACS chemical biology · 2010Article
- Grand challenge commentary: Synthetic immunology to engineer human immunity.Nature chemical biology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The ability to instantly create a state of immunity as achieved in the passive transfer of hyperimmune globulin has had a tremendous impact on public health. Unlike passive immunization, active immunization, which is the foundation of vaccinology, is an anticipatory strategy with inherent limitations. Here we show that elements of active and passive immunization can be combined to create an effective chemistry-driven approach to vaccinology. Reactive immunization was used to create a reservoir of covalent polyclonal antibodies in 3 mouse strains that were subsequently engrafted with syngeneic CT26 colon or B16F10 melanoma tumors. Upon administration of designed integrin alpha(v)beta(3) and alpha(v)beta(5) adapter ligands, the induced covalent polyclonal antibodies self-assembled with the adapter ligands and the animals mounted an instant, chemically programmed, polyclonal response against the implanted tumors. Significant therapeutic responses were observed without recourse to adjuvant therapy. The chemically programmed immune responses were driven by antibody-dependent cellular cytotoxicity and complement-directed cytotoxicity. We suggest that this type of chemistry-driven approach to vaccinology is underexplored and may provide routes to vaccines to protect against diseases that have proven intractable to biology-driven vaccine approaches.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.