ArticleGenetics2009
Mutations in two zinc-cluster proteins activate alternative respiratory and gluconeogenic pathways and restore senescence in long-lived respiratory mutants of Podospora anserina.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Regulatory functions of AcuK and AcuM transcription factors in fungal metabolic adaptation, stress response, and virulence.Frontiers in cellular and infection microbiology · 2025Review
- AcuM and AcuK: The global regulators controlling multiple cellular metabolisms in a dimorphic fungus Talaromyces marneffei.PLoS neglected tropical diseases · 2024Article
- Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence.Nature communications · 2023Article
- Genetic and functional analysis of the Zn(II)Applied microbiology and biotechnology · 2021Article
- A Network of Pathways Controlling Cellular Homeostasis Affects the Onset of Senescence inJournal of fungi (Basel, Switzerland) · 2021Review
- Characterization of Single Gene Deletion Mutants Affecting Alternative Oxidase Production inMicroorganisms · 2020Article
- Involvement of a G Protein Regulatory Circuit in Alternative Oxidase Production inG3 (Bethesda, Md.) · 2019Article
- Analysis of the Relationship between Alternative Respiration and Sterigmatocystin Formation inToxins · 2018Article
- Alternative Oxidase Transcription Factors AOD2 and AOD5 ofG3 (Bethesda, Md.) · 2017Article
- Regulation of Aerobic Energy Metabolism in Podospora anserina by Two Paralogous Genes Encoding Structurally Different c-Subunits of ATP Synthase.PLoS genetics · 2016Article
- Genetic and functional investigation of Zn(2)Cys(6) transcription factors RSE2 and RSE3 in Podospora anserina.Eukaryotic cell · 2014Article
- Identification of genes required for alternative oxidase production in the Neurospora crassa gene knockout library.G3 (Bethesda, Md.) · 2012Article
- Effects of calorie restriction on life span of microorganisms.Applied microbiology and biotechnology · 2010Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In Podospora anserina, inactivation of the respiratory chain results in a spectacular life-span extension. This inactivation is accompanied by the induction of the alternative oxidase. Although the functional value of this response is evident, the mechanism behind it is far from understood. By screening suppressors able to reduce the life-span extension of cytochrome-deficient mutants, we identified mutations in two zinc-cluster proteins, RSE2 and RSE3, which are conserved in other ascomycetes. These mutations led to the overexpression of the genes encoding the alternative oxidase and the gluconeogenic enzymes, fructose-1, 6 biphosphatase, and pyruvate carboxykinase. Both RSE2 and RSE3 are required for the expression of these genes. We also show that, even in the absence of a respiratory deficiency, the wild-type RSE2 and RSE3 transcription factors are involved in life-span control and their inactivation retards aging. These data are discussed with respect to aging, the regulation of the alternative oxidase, and carbon metabolism.
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Registered trials
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