ArticleChest2009
Soluble p-selectin and the risk of primary graft dysfunction after lung transplantation.
Article in Chest, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction.American journal of respiratory and critical care medicine · 2014Trial
- Lung rehabilitation using xenogeneic cross-circulation does not lead to hyperacute rejection in a human lung transplantation model.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- Primary graft dysfunction after Lung transplantation: unveiling the role of innate immunity.Clinical and experimental immunology · 2025Article
- Primary graft dysfunction following lung transplantation: From pathogenesis to future frontiers.World journal of transplantation · 2023Review
- Risk of primary graft dysfunction following lung transplantation in selected adults with connective tissue disease-associated interstitial lung disease.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs.Nature medicine · 2020Article
- Novel Strategies for Endothelial Preservation in Lung Transplant Ischemia-Reperfusion Injury.Frontiers in physiology · 2020Review
- Protein biomarkers associated with primary graft dysfunction following lung transplantation.American journal of physiology. Lung cellular and molecular physiology · 2017Review
- Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation.American journal of respiratory and critical care medicine · 2015Article
- Gprc5a-deficiency confers susceptibility to endotoxin-induced acute lung injury via NF-κB pathway.Cell cycle (Georgetown, Tex.) · 2015Article
- Primary graft dysfunction.Seminars in respiratory and critical care medicine · 2013Review
- Clinical risk factors for primary graft dysfunction after lung transplantation.American journal of respiratory and critical care medicine · 2013Article
- Update on lung transplantation: programmes, patients and prospects.European respiratory review : an official journal of the European Respiratory Society · 2012Review
- Article
- Postoperative estradiol levels associate with development of primary graft dysfunction in lung transplantation patients.Gender medicine · 2012Article
- Obesity and primary graft dysfunction after lung transplantation: the Lung Transplant Outcomes Group Obesity Study.American journal of respiratory and critical care medicine · 2011Article
- Article
- Elevated plasma clara cell secretory protein concentration is associated with high-grade primary graft dysfunction.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2011Article
- Platelets: versatile modifiers of innate and adaptive immune responses to transplants.Current opinion in organ transplantation · 2011Review
- Genetic polymorphisms associated with acute lung injury.Pharmacogenomics · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundPlatelet activation with subsequent neutrophilic adherence to the vasculature initiates ischemia-reperfusion injury. We hypothesized that higher plasma P-selectin levels reflecting platelet activation would therefore be associated with primary graft dysfunction (PGD) after lung transplantation.
methodsIn a prospective, multicenter cohort study of 376 patients who had undergone lung transplantation between 2002 and 2007, we measured soluble P-selectin levels before lung transplantation and at 6 and 24 h after lung reperfusion in 20 patients with grade III PGD (Pao(2)/fraction of inspired oxygen, < 200 mm Hg [with alveolar infiltrates seen on chest radiographs]) at 72 h after transplantation and 61 control subjects without PGD.
resultsHigher postoperative soluble P-selectin levels were associated with an increased risk of PGD at 72 h after transplantation (odds ratio [OR] per 1 natural log increase in soluble P-selectin at 6 h after lung allograft reperfusion, 3.5; 95% confidence interval [CI], 1.01 to 11.8; p = 0.048) and at 24 h after lung allograft reperfusion (OR, 4.8; 95% CI, 1.4 to 16.1; p = 0.01). Higher preoperative mean pulmonary artery pressure and the use of cardiopulmonary bypass were also associated with an increased risk of PGD.
conclusionHigher postoperative soluble P-selectin levels were associated with an increased risk of PGD at 72 h following lung transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.