ArticleThe American journal of psychiatry2009
Identification of a schizophrenia-associated functional noncoding variant in NOS1AP.
Article in The American journal of psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 67 citations in OpenAlex.
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- Metabolomics Network Analysis of Various Genotypes Associated with Schizophrenia Gene Variant.Metabolites · 2025Article
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- Decreased CNNM2 expression in prefrontal cortex affects sensorimotor gating function, cognition, dendritic spine morphogenesis and risk of schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- PPARD rs2016520 (T/C) and NOS1AP rs12742393 (A/C) polymorphisms affect therapeutic efficacy of nateglinide in Chinese patients with type 2 diabetes mellitus.BMC medical genomics · 2021Article
- The PPLD has advantages over conventional regression methods in application to moderately sized genome-wide association studies.PloS one · 2021Article
- Genetic Factors of Nitric Oxide's System in Psychoneurologic Disorders.International journal of molecular sciences · 2020Review
- Genetic Intersections of Language and Neuropsychiatric Conditions.Current psychiatry reports · 2020Review
- Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its PDZ binding domain.EBioMedicine · 2019Article
- Validation of a microRNA target site polymorphism in H3F3B that is potentially associated with a broad schizophrenia phenotype.PloS one · 2018Article
- Psychiatric behaviors associated with cytoskeletal defects in radial neuronal migration.Cellular and molecular life sciences : CMLS · 2017Review
- Overexpression of Isoforms of Nitric Oxide Synthase 1 Adaptor Protein, Encoded by a Risk Gene for Schizophrenia, Alters Actin Dynamics and Synaptic Function.Frontiers in cellular neuroscience · 2016Article
- Nitric oxide synthase 1 adaptor protein, a protein implicated in schizophrenia, controls radial migration of cortical neurons.Biological psychiatry · 2015Article
- Role of nitric oxide and related molecules in schizophrenia pathogenesis: biochemical, genetic and clinical aspects.Frontiers in physiology · 2015Review
- Article
- Revisiting schizophrenia linkage data in the NIMH Repository: reanalysis of regularized data across multiple studies.The American journal of psychiatry · 2014Article
- Critical role of nitric oxide in the modulation of prepulse inhibition in Swiss mice.Psychopharmacology · 2014Article
- Serum Proteome Changes in Healthy Subjects with Different Genotypes of NOS1AP in the Chinese Population.Journal of diabetes research · 2013Article
- Early environmental exposures influence schizophrenia expression even in the presence of strong genetic predisposition.Schizophrenia research · 2012Article
- New roles of carboxypeptidase E in endocrine and neural function and cancer.Endocrine reviews · 2012Review
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe authors previously demonstrated significant association between markers within NOS1AP and schizophrenia in a set of Canadian families of European descent, as well as significantly increased expression in schizophrenia of NOS1AP in unrelated postmortem samples from the dorsolateral prefrontal cortex. In this study the authors sought to apply novel statistical methods and conduct additional biological experiments to isolate at least one risk allele within NOS1AP.
methodUsing the posterior probability of linkage disequilibrium (PPLD) to measure the probability that a single nucleotide polymorphism (SNP) is in linkage disequilibrium with schizophrenia, the authors evaluated 60 SNPs from NOS1AP in 24 Canadian families demonstrating linkage and association to this region. SNPs exhibiting strong evidence of linkage disequilibrium were tested for regulatory function by luciferase reporter assay. Two human neural cell lines (SK-N-MC and PFSK-1) were transfected with a vector containing each allelic variant of the SNP, the NOS1AP promoter, and a luciferase gene. Alleles altering expression were further assessed for binding of nuclear proteins by electrophoretic mobility shift assay.
resultsThree SNPs produced PPLDs >40%. One of them, rs12742393, demonstrated significant allelic expression differences in both cell lines tested. The allelic variation at this SNP altered the affinity of nuclear protein binding to this region of DNA.
conclusionsThe A allele of rs12742393 appears to be a risk allele associated with schizophrenia that acts by enhancing transcription factor binding and increasing gene expression.
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