ArticlePhysiology & behavior2009
Depression-like behavior of aged male and female mice is ameliorated with administration of testosterone or its metabolites.
Article in Physiology & behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 91 citations in OpenAlex.
- Aromatase inhibition and ketamine in rats: sex-differences in antidepressant-like efficacy.Biology of sex differences · 2023Article
- Aromatase Inhibition and Electroconvulsive Seizures in Adolescent Rats: Antidepressant and Long-Term Cognitive Sex Differences.The international journal of neuropsychopharmacology · 2023Article
- Sex Differences in Depression and Anxiety.Current topics in behavioral neurosciences · 2023Article
- Pubertal Emergence of Testosterone Effects on Depressive Symptoms in Boys.JCPP advances · 2022Article
- Article
- Sex Differences in Major Depressive Disorder (MDD) and Preclinical Animal Models for the Study of Depression.Cold Spring Harbor perspectives in biology · 2022Review
- Testosterone Replacement Therapy in the Treatment of Depression.Health psychology research · 2022Article
- The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli.Biomolecules · 2019Article
- Neurobiological mechanisms underlying sex-related differences in stress-related disorders: Effects of neuroactive steroids on the hippocampus.Frontiers in neuroendocrinology · 2019Review
- Testosterone imbalance may link depression and increased body weight in premenopausal women.Translational psychiatry · 2019Article
- Role of HPA and the HPG Axis Interaction in Testosterone-Mediated Learned Helpless Behavior.Molecular neurobiology · 2019Article
- The Impact of Hippocampal Sex Hormones Receptors in Modulation of Depressive-Like Behavior Following Chronic Anabolic Androgenic Steroids and Exercise Protocols in Rats.Frontiers in behavioral neuroscience · 2019Article
- Aging alters the immunological response to ischemic stroke.Acta neuropathologica · 2018Article
- Neuroactive Steroids and Affective Symptoms in Women Across the Weight Spectrum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Alterations of the oxidative status in rat hippocampus and prodepressant effect of chronic testosterone enanthate administration.Molecular and cellular biochemistry · 2017Article
- Antidepressant-Like Effect of Ropren® in β-Amyloid-(25-35) Rat Model of Alzheimer's Disease with Altered Levels of Androgens.Molecular neurobiology · 2017Article
- Animal models to improve our understanding and treatment of suicidal behavior.Translational psychiatry · 2017Review
- Strain and sex based characterization of behavioral expressions in non-induced compulsive-like mice.Physiology & behavior · 2017Article
- Article
- Prenatal and Early Postnatal Exposure to Cigarette Smoke Decreases BDNF/TrkB Signaling and Increases Abnormal Behaviors Later in Life.The international journal of neuropsychopharmacology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
There may be a role of age-related decline in androgen production and/or its metabolism for late-onset depression disorders of men and women. Thus, the anti-depressant-like effects of testosterone (T) and its metabolites are of interest. Given that these androgens have disparate mechanisms of action, it is important to begin to characterize and compare their effects in an aged animal model. We hypothesized that there would be sex differences in depression behavior of aged mice and that androgens would reduce depression-like behaviors in the forced swim test. To investigate this, male and female mice (approximately 24 months old) were subcutaneously administered T, or one of its 5alpha-reduced metabolites (dihydrotesterone-DHT, 5alpha-androstane,17beta-diol-3alpha-diol), or aromatized metabolite (estradiol--E(2)), or oil vehicle. Mice were administered androgens (1 mg/kg) 1 h before being tested in the forced swim test, an animal model of depression. We found that males spent more time immobile, and less time swimming, than females. Administration of T, DHT, or 3alpha-diol similarly reduced time spent immobile, and increased time spent struggling, of male and female mice. E(2), compared to vehicle administration, decreased time spent immobile of males and females, but increased time spent swimming of females and time spent struggling of male mice. Together, these data suggest that T and its 5alpha-reduced and aromatized metabolites have anti-depressant-like effects in aged male and female mice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.