ArticlePhysiology & behavior2009
Pregnancy decreases GABAergic inhibition of the hypothalamic paraventricular nucleus.
Article in Physiology & behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Important Role of Renin-Angiotensin System and Vasopressin System in Cardiovascular, Metabolic and Psychogenic Disorders in Pregnancy and Early Postnatal Life: A Narrative Review.International journal of molecular sciences · 2026Review
- Function of the GABAergic System in Diabetic Encephalopathy.Cellular and molecular neurobiology · 2023Review
- Adaptations in autonomic nervous system regulation in normal and hypertensive pregnancy.Handbook of clinical neurology · 2020Review
- Sympathetic nervous system control of vascular function and blood pressure during pregnancy and preeclampsia.Journal of hypertension · 2019Review
- Regulation of sympathetic vasomotor activity by the hypothalamic paraventricular nucleus in normotensive and hypertensive states.American journal of physiology. Heart and circulatory physiology · 2018Review
- Muscle sympathetic nerve activity and volume-regulating factors in healthy pregnant and nonpregnant women.American journal of physiology. Heart and circulatory physiology · 2017Article
- Hypothalamic Paraventricular and Arcuate Nuclei Contribute to Elevated Sympathetic Nerve Activity in Pregnant Rats: Roles of Neuropeptide Y and α-Melanocyte-Stimulating Hormone.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Regulation of arterial pressure by the paraventricular nucleus in conscious rats: interactions among glutamate, GABA, and nitric oxide.Frontiers in physiology · 2012Article
- GABA in the paraventricular nucleus tonically suppresses baroreflex function: alterations during pregnancy.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Pregnancy and the endocrine regulation of the baroreceptor reflex.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Depressor responses to peripheral or central infusion of Angiotensin II type 1 (AT(1)) receptor antagonists (AT(1)X) are greater in pregnant (P) compared to nonpregnant (NP) animals. AT(1) and ionotropic excitatory amino acid (EAA) receptors contribute to pressor responses to GABA(A) receptor blockade with bicuculline (Bic) in the paraventricular nucleus (PVN) of male rats. Therefore, we hypothesized that GABAergic inhibition is decreased and AT(1) receptors play a greater excitatory role in the PVN of P versus NP rats. Unilateral microinjection of Bic was performed before (Bic(1)), after AT(1)X (Bic(2)), and after AT(1)X + EAA blockade (kynurenate, Kyn) (Bic(3)) in the PVN. Increases in mean arterial pressure (MAP: NP=20+/-2; P=12+/-2 mmHg), heart rate (HR: NP=57+/-6; P=19+/-6 beats/min) and renal sympathetic nerve activity (RSNA: NP=70+/-9; P=33+/-7%) due to Bic (Bic(1)) were attenuated in P rats. Responses to AT(1)X and Kyn alone were insignificant in both groups. In NP rats, AT(1)X attenuated (+12+/-4 mmHg), and AT(1)X + Kyn further decreased the pressor response to Bic in the PVN (+6+/-2 mmHg). In P rats AT(1)X reduced the pressor response to Bic (+5+/-1 mm Hg), and Kyn had no additional effect (+3+/-1 mmHg). Effects of PVN Bic to alter the autospectra of RSNA were suppressed by prior AT(1)X and Kyn in both groups. Thus, tonic GABAergic inhibition is decreased and the contribution of AT(1) receptors in the PVN may be greater in P rats.
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