ArticlePhysiology & behavior2009
Effect of a putative ERalpha antagonist, MPP, on food intake in cycling and ovariectomized rats.
Article in Physiology & behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Estrogen Receptor Alpha (ERα) Is Involved in Resveratrol-Mediated Muscle Preservation During Mechanical Unloading in Male Rats.Muscles (Basel, Switzerland) · 2026Article
- An exploratory microarray analysis of estrogen-mediated gene expression in central pathways that control energy balance in female rats (Rattus norvegicus).BMC research notes · 2026Article
- Estrogen receptor-α ablation reverses muscle fibrosis and inguinal hernias.The Journal of clinical investigation · 2025Article
- Inhibition of Estradiol Signaling in the Basolateral Amygdala Impairs Extinction Memory Recall for Heroin-Conditioned Cues in a Sex-Specific Manner.Neuroendocrinology · 2024Article
- Relationship Between Circulating Metabolic Hormones and Their Central Receptors During Ovariectomy-Induced Weight Gain in Rats.Frontiers in physiology · 2021Article
- Vulnerability to psychological stress-induced anorexia in female mice depends on blockade of ghrelin signal in nucleus tractus solitarius.British journal of pharmacology · 2020Article
- Selective activation of estrogen receptors, ERα and GPER-1, rapidly decreases food intake in female rats.Hormones and behavior · 2018Article
- Notoginsenoside RRSC advances · 2018Article
- Ovarian function's role during cancer cachexia progression in the female mouse.American journal of physiology. Endocrinology and metabolism · 2017Article
- Serotonin transporter deficiency drives estrogen-dependent obesity and glucose intolerance.Scientific reports · 2017Article
- Article
- Estrogen receptor ERα plays a major role in ethanol-evoked myocardial oxidative stress and dysfunction in conscious female rats.Alcohol (Fayetteville, N.Y.) · 2016Article
- Sex and estrogens alter the action of glucagon-like peptide-1 on reward.Biology of sex differences · 2016Article
- Multiple estrogen receptor subtypes influence ingestive behavior in female rodents.Physiology & behavior · 2015Review
- Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice.Psychopharmacology · 2015Article
- Estrogen provides neuroprotection against brain edema and blood brain barrier disruption through both estrogen receptors α and β following traumatic brain injury.Iranian journal of basic medical sciences · 2015Article
- The effect of Momordica charantia intake on the estrogen receptors ESRα/ESRβ gene levels and apoptosis on uterine tissue in ovariectomy rats.Molecular biology reports · 2015Article
- Activation of membrane-associated estrogen receptors decreases food and water intake in ovariectomized rats.Endocrinology · 2013Article
- Sex differences in selecting between food and cocaine reinforcement are mediated by estrogen.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Article
- Functions and physiological roles of two types of estrogen receptors, ERα and ERβ, identified by estrogen receptor knockout mouse.Laboratory animal research · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Estrogens exert many of their behavioral effects by binding to nuclear estrogen receptor (ER) proteins, ERalpha and ERbeta. Recent studies involving ER knockout mice and selective ER agonists suggest that estradiol's anorexigenic effect is mediated via activation of ERalpha. To investigate this hypothesis, we examined whether the presumptive ERalpha antagonist, MPP, could block estradiol's anorexigenic effect. In the first series of experiments, the effects of MPP on food intake and uterine weight were monitored in ovariectomized (OVX) rats treated with either a physiological dose of estradiol benzoate (EB) or a selective ERalpha agonist (PPT). In the final experiment, food intake was monitored following acute administration of MPP in ovarian-intact (cycling) female rats. Contrary to our hypothesis, MPP failed to attenuate either EB's or PPT's ability to decrease food intake and increase uterine weight in OVX rats. However, in ovarian-intact rats, a similar regimen of MPP treatment attenuated the phasic decrease in food intake that is associated with estrus. We conclude that MPP may be a useful tool to investigate the behavioral actions of endogenous estradiol, but may have limited utility in studying the behavioral effects of exogenous estradiol in OVX rats.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.