ReviewInternational journal for parasitology2009
Development of forward genetics in Toxoplasma gondii.
Review in International journal for parasitology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Integrating design-of-experiments (DOE) optimization and risk assessment towards a safe and simplified electroporation protocol for Toxoplasma gondii.PLoS neglected tropical diseases · 2026Article
- Global geographical distribution ofParasite epidemiology and control · 2025Review
- A major locus confers triclabendazole resistance in Fasciola hepatica and shows dominant inheritance.PLoS pathogens · 2023Article
- Genetic Crosses and Linkage Mapping in Schistosome Parasites.Trends in parasitology · 2018Review
- Congenital toxoplasmosis: an in-depth density-equalizing mapping analysis to explore its global research architecture.Parasites & vectors · 2015Article
- Genetic mapping reveals that sinefungin resistance in Toxoplasma gondii is controlled by a putative amino acid transporter locus that can be used as a negative selectable marker.Eukaryotic cell · 2015Article
- Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites.Science (New York, N.Y.) · 2013Article
- Strategies to discover the structural components of cyst and oocyst walls.Eukaryotic cell · 2013Review
- Modulation of innate immunity by Toxoplasma gondii virulence effectors.Nature reviews. Microbiology · 2012Review
- Molecular parasitology in the 21st century.Essays in biochemistry · 2011Review
- A major genetic locus in Trypanosoma brucei is a determinant of host pathology.PLoS neglected tropical diseases · 2009Article
- A century of Toxoplasma research.International journal for parasitology · 2009Article
- The early years of Toxoplasma research: What's past is prologue.International journal for parasitology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The development of forward genetics as a functional system in Toxoplasma gondii spanned more than three decades from the mid-1970s until now. The initial demonstration of experimental genetics relied on chemically induced drug-resistant mutants that were crossed by co-infecting cats, collecting oocysts, sporulating and hatching progeny in vitro. To capitalise on this, genetic markers were employed to develop linkage maps by tracking inheritance through experimental crosses. In all, three generations of genetic maps were developed to define the chromosomes, estimate recombination rates and provide a system for linkage analysis. Ultimately this genetic map would become the foundation for the assembly of the T. gondii genome, which was derived from whole genome shotgun sequencing, into a chromosome-centric view. Finally, application of forward genetics to multigenic biological traits showed the potential to map and identify specific genes that control complex phenotypes including virulence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.