ArticleCell metabolism2009
Iron sensing as a partnership: HFE and transferrin receptor 2.
Article in Cell metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Article
- Characterization ofBlood advances · 2018Article
- The Dual Role of Hepcidin in Brain Iron Load and Inflammation.Frontiers in neuroscience · 2018Review
- Brain Iron Metabolism Dysfunction in Parkinson's Disease.Molecular neurobiology · 2017Review
- HJV and HFE Play Distinct Roles in Regulating Hepcidin.Antioxidants & redox signaling · 2015Article
- Factors influencing disease phenotype and penetrance in HFE haemochromatosis.Human genetics · 2010Review
- Anemic copper-deficient rats, but not mice, display low hepcidin expression and high ferroportin levels.The Journal of nutrition · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The mechanism by which HFE participates in the regulation of iron homeostasis has remained enigmatic. Gao et al. (2009) make the key discovery that the regulation of hepcidin in response to holotransferrin requires the interaction between HFE and transferrin receptor 2 (TfR2).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.