ArticleNeural development2009
Cell proliferation in the Drosophila adult brain revealed by clonal analysis and bromodeoxyuridine labelling.
Article in Neural development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- The Repair Manual of a Fruit Fly Brain.International journal of molecular sciences · 2026Review
- Cell cycle re-entry in the agingbioRxiv : the preprint server for biology · 2024Article
- The impact of developmental stage, tissue type, and sex on DNA double-strand break repair in Drosophila melanogaster.PLoS genetics · 2024Article
- Homemade: building the structure of the neurogenic niche.Frontiers in cell and developmental biology · 2023Review
- Insights into nervous system repair from the fruit fly.Neuronal signaling · 2022Review
- Stimulating and Analyzing Adult Neurogenesis in the Drosophila Central Brain.Journal of visualized experiments : JoVE · 2021Article
- Neurogenesis in the adult Drosophila brain.Genetics · 2021Article
- Adult Neurogenesis in theInternational journal of molecular sciences · 2020Review
- Polyploidy in the adulteLife · 2020Article
- Adult neurogenesis in the mushroom bodies of red flour beetles (Tribolium castaneum, HERBST) is influenced by the olfactory environment.Scientific reports · 2020Article
- Adult Drosophila Lack Hematopoiesis but Rely on a Blood Cell Reservoir at the Respiratory Epithelia to Relay Infection Signals to Surrounding Tissues.Developmental cell · 2019Article
- Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation.eLife · 2019Article
- E93 Integrates Neuroblast Intrinsic State with Developmental Time to Terminate MB Neurogenesis via Autophagy.Current biology : CB · 2019Article
- RanGAP-mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain.Aging cell · 2019Article
- Structural and Functional Abnormalities in the Olfactory System of Fragile X Syndrome Models.Frontiers in molecular neuroscience · 2019Review
- A Novel Mutation in Brain Tumor Causes Both Neural Over-Proliferation and Neurodegeneration in AdultG3 (Bethesda, Md.) · 2018Article
- A Brain Unfixed: Unlimited Neurogenesis and Regeneration of the Adult Planarian Nervous System.Frontiers in neuroscience · 2017Article
- A Drosophila model to investigate the neurotoxic side effects of radiation exposure.Disease models & mechanisms · 2015Article
- MANF silencing, immunity induction or autophagy trigger an unusual cell type in metamorphosing Drosophila brain.Cellular and molecular life sciences : CMLS · 2015Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe production of new neurons during adulthood and their subsequent integration into a mature central nervous system have been shown to occur in all vertebrate species examined to date. However, the situation in insects is less clear and, in particular, it has been reported that there is no proliferation in the Drosophila adult brain.
resultsWe report here, using clonal analysis and 5'-bromo-2'-deoxyuridine (BrdU) labelling, that cell proliferation does occur in the Drosophila adult brain. The majority of clones cluster on the ventrolateral side of the antennal lobes, as do the BrdU-positive cells. Of the BrdU-labelled cells, 86% express the glial gene reversed polarity (repo), and 14% are repo negative.
conclusionWe have observed cell proliferation in the Drosophila adult brain. The dividing cells may be adult stem cells, generating glial and/or non-glial cell types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.