ArticleNeural development2009
Cytoplasmic polyadenylation and cytoplasmic polyadenylation element-dependent mRNA regulation are involved in Xenopus retinal axon development.
Article in Neural development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Translational activation of maternally derived mRNAs in oocytes and early embryos and the role of embryonic poly(A) binding protein (EPAB).Biology of reproduction · 2019Review
- Filopodyan: An open-source pipeline for the analysis of filopodia.The Journal of cell biology · 2017Article
- Regulation of Adult CNS Axonal Regeneration by the Post-transcriptional Regulator Cpeb1.Frontiers in molecular neuroscience · 2017Article
- Hermes Regulates Axon Sorting in the Optic Tract by Post-Trancriptional Regulation of Neuropilin 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- RNA-binding proteins in eye development and disease: implication of conserved RNA granule components.Wiley interdisciplinary reviews. RNA · 2016Review
- Loss of CPEB3 Upregulates MEGF10 to Impair Mosaic Development of ON Starburst Amacrine Cells.Frontiers in molecular neuroscience · 2016Article
- Article
- Molecular determinants of the axonal mRNA transcriptome.Developmental neurobiology · 2014Review
- Coupling of NF-protocadherin signaling to axon guidance by cue-induced translation.Nature neuroscience · 2013Article
- RNA-binding proteins and translational regulation in axons and growth cones.Frontiers in neuroscience · 2013Article
- Translational control of mitochondrial energy production mediates neuron morphogenesis.Cell metabolism · 2012Article
- Cytoplasmic RNA-binding proteins and the control of complex brain function.Cold Spring Harbor perspectives in biology · 2012Review
- Insights into the roles of local translation from the axonal transcriptome.Open biology · 2012Review
- Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair.Nature reviews. Neuroscience · 2012Review
- Translational regulation in growth cones.Current opinion in genetics & development · 2011Review
- Axonal commissures in the central nervous system: how to cross the midline?Cellular and molecular life sciences : CMLS · 2011Review
- Netrin-1-induced local β-actin synthesis and growth cone guidance requires zipcode binding protein 1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Subcellular profiling reveals distinct and developmentally regulated repertoire of growth cone mRNAs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local beta-actin synthesis and growth cone turning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Dynamics of axonal mRNA transport and implications for peripheral nerve regeneration.Experimental neurology · 2010Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
backgroundTranslation in axons is required for growth cone chemotropic responses to many guidance cues. Although locally synthesized proteins are beginning to be identified, how specific mRNAs are selected for translation remains unclear. Control of poly(A) tail length by cytoplasmic polyadenylation element (CPE) binding protein 1 (CPEB1) is a conserved mechanism for mRNA-specific translational regulation that could be involved in regulating translation in axons.
resultsWe show that cytoplasmic polyadenylation is required in Xenopus retinal ganglion cell (RGC) growth cones for translation-dependent, but not translation-independent, chemotropic responses in vitro, and that inhibition of CPE binding through dominant-negative interference severely reduces axon outgrowth in vivo. CPEB1 mRNA transcripts are present at low levels in RGCs but, surprisingly, CPEB1 protein was not detected in eye or brain tissue, and CPEB1 loss-of-function does not affect chemotropic responses or pathfinding in vivo. UV cross-linking experiments suggest that CPE-binding proteins other than CPEB1 in the retina regulate retinal axon development.
conclusionThese results indicate that cytoplasmic polyadenylation and CPE-mediated translational regulation are involved in retinal axon development, but that CPEB1 may not be the key regulator of polyadenylation in the developing retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.