ArticleJournal of periodontology2009
Neutrophil formylpeptide receptor single nucleotide polymorphism 348T>C in aggressive periodontitis.
Article in Journal of periodontology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Periodontal health and disease: The contribution of genetics.Periodontology 2000 · 2021Review
- Primary Immunodeficiencies With Defects in Innate Immunity: Focus on Orofacial Manifestations.Frontiers in immunology · 2020Review
- The ambiguous role of FPR1 in immunity and inflammation.Oncoimmunology · 2020Article
- Periodontal tissue destruction in aggressive periodontitis: Determination of gene or environmental factors.The Saudi dental journal · 2019Article
- Genetic polymorphisms and periodontal disease in populations of African descent: A review.Journal of periodontal research · 2018Review
- Periodontal conditions in patients with Marfan syndrome - a multicenter case control study.BMC oral health · 2013Article
- V101L of human formyl peptide receptor 1 (FPR1) increases receptor affinity and augments the antagonism mediated by cyclosporins.The Biochemical journal · 2013Article
- Neutrophils in periodontal inflammation.Frontiers of oral biology · 2012Review
- Article
- Two novel cSNPs of weaver gene in Chinese indigenous goat and their associations with milk yield.Molecular biology reports · 2010Article
- Formylpeptide receptor single nucleotide polymorphism 348T>C and its relationship to polymorphonuclear leukocyte chemotaxis in aggressive periodontitis.Journal of periodontology · 2009Article
- Formyl peptide receptor 1 suppresses gastric cancer angiogenesis and growth by exploiting inflammation resolution pathways.OncoimmunologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundNeutrophil formylpeptide receptors (FPRs) play an important role in bacterial recognition and chemotaxis. Defective FPR1 expression and impaired polymorphonuclear leukocyte chemotaxis toward bacterial formylpeptides are associated with aggressive periodontitis (AgP). The objective of this study was to determine whether single nucleotide polymorphisms (SNPs) in FPR1 are associated with AgP.
methodsGenomic DNA was isolated from blood samples obtained from African Americans (30 subjects with AgP and 33 healthy controls) and Turks (75 subjects with AgP and 63 healthy controls). A highly polymorphic fragment of the FPR1 gene was amplified by polymerase chain reaction and sequenced for analysis of SNPs.
resultsFive previously identified SNPs were detected in African Americans, whereas six were detected in Turkish subjects. The frequency of synonymous SNP c.348T>C was significantly higher in African Americans with AgP than in controls (P = 0.029). The 348T allele was significantly associated with AgP (P = 0.010). Seven of the subjects with AgP, but none of the controls, were homozygous for 348T. FPR1 haplotypes 348T.568A, 348T.576T, and 348T.568A.576T were significantly increased in African Americans with AgP (P <0.02). The Turkish population did not exhibit significant differences in FPR1 SNP frequencies between subjects with AgP and controls.
conclusionsFPR1 SNP c.348T>C is associated with AgP in African Americans. Individuals who are homozygous for 348T may have an increased risk for developing this disorder.
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Registered trials
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