ArticleTissue engineering. Part A2009
Polyphenol-stabilized tubular elastin scaffolds for tissue engineered vascular grafts.
Article in Tissue engineering. Part A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
- Polyphenols as Natural Therapeutics for Dental Infections and Oral Inflammation: Mechanisms and Clinical Perspectives.Chemistry & biodiversity · 2026Review
- Article
- Biological properties of self-assembled nanofibers of elastin-like block polypeptides for tissue-engineered vascular grafts: platelet inhibition, endothelial cell activation and smooth muscle cell maintenance.Regenerative biomaterials · 2023Article
- Decellularized blood vessel development: Current state-of-the-art and future directions.Frontiers in bioengineering and biotechnology · 2022Review
- Animal Model Dependent Response to Pentagalloyl Glucose in Murine Abdominal Aortic Injury.Journal of clinical medicine · 2021Article
- Pentagalloyl glucose (PGG) partially prevents arterial mechanical changes due to elastin degradation.Experimental mechanics · 2021Article
- Elastin-Based Materials: Promising Candidates for Cardiac Tissue Regeneration.Frontiers in bioengineering and biotechnology · 2020Review
- Pentagalloyl Glucose and Its Functional Role in Vascular Health: Biomechanics and Drug-Delivery Characteristics.Annals of biomedical engineering · 2019Review
- Polyphenol uses in biomaterials engineering.Biomaterials · 2018Review
- Challenges in vascular tissue engineering for diabetic patients.Acta biomaterialia · 2018Review
- Elastin-PLGA hybrid electrospun nanofiber scaffolds for salivary epithelial cell self-organization and polarization.Acta biomaterialia · 2017Article
- Delivery of Antioxidant and Anti-inflammatory Agents for Tissue Engineered Vascular Grafts.Frontiers in pharmacology · 2017Review
- Immunomodulatory effects of adipose tissue-derived stem cells on elastin scaffold remodeling in diabetes.Tissue engineering and regenerative medicine · 2016Article
- Stabilized Collagen and Elastin-Based Scaffolds for Mitral Valve Tissue Engineering.Tissue engineering. Part A · 2016Article
- Bioreactor Conditioning of Valve Scaffolds Seeded Internally with Adult Stem Cells.Tissue engineering and regenerative medicine · 2016Article
- Heterogeneity of Scaffold Biomaterials in Tissue Engineering.Materials (Basel, Switzerland) · 2016Review
- Preclinical evaluation of collagen type I scaffolds, including gelatin-collagen microparticles and loaded with a hydroglycolic Calendula officinalis extract in a lagomorph model of full-thickness skin wound.Drug delivery and translational research · 2016Article
- Article
- Platform technologies for decellularization, tunic-specific cell seeding, and in vitro conditioning of extended length, small diameter vascular grafts.Tissue engineering. Part C, Methods · 2014Article
- The performance of cross-linked acellular arterial scaffolds as vascular grafts; pre-clinical testing in direct and isolation loop circulatory models.Biomaterials · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Tissue-engineered vascular grafts require elastic, acellular porous scaffolds with controlled biodegradability and properties matching those of natural arteries. Elastin would be a desirable component for such applications, but elastin does not easily regenerate experimentally. Our approach is to develop tubular elastin scaffolds using decellularization and removal of collagen from porcine carotid arteries ( approximately 5 mm diameter) using alkaline extraction. Because elastin is susceptible to rapid degeneration after implantation, scaffolds were further treated with penta-galloyl glucose (PGG), an established polyphenolic elastin-stabilizing agent. Scaffolds were compared in vitro with detergent-decellularized arteries for structure, composition, resistance to degradation, mechanical properties, and cytotoxicity and in vivo for cell infiltration and remodeling potential. Results showed effective decellularization and almost complete collagen removal by alkaline extraction. PGG-treated elastin scaffolds proved to be resistant to elastase digestion in vitro, maintained their cylindrical shapes, showed high resistance to burst pressures, and supported growth of endothelial cells and fibroblasts. In vivo results showed that PGG treatment reduced the rate of elastin biodegradation and controlled cell infiltration but did not hamper new collagen and proteoglycan deposition and secretion of matrix-degrading proteases. Alkali-purified, PGG-treated tubular arterial elastin scaffolds exhibit many desirable properties to be recommended for clinical applications as vascular grafts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.