ArticleAnalytical chemistry2009
High-throughput cell and particle characterization using isodielectric separation.
Article in Analytical chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Integrated microfluidic biosensors: shaping the future of quantitative life sciences and on-chip molecular diagnostics.Lab on a chip · 2026Review
- Biomarker analysis from complex biofluids by an on-chip chemically modified light-controlled vertical nanopillar array device.Nature protocols · 2025Review
- Isolation Techniques of Micro/Nano-Scaled Species for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Acoustic separation and concentration of exosomes for nucleotide detection: ASCENDx.Science advances · 2024Article
- A High-Throughput Microfluidic Cell Sorter Using a Three-Dimensional Coupled Hydrodynamic-Dielectrophoretic Pre-Focusing Module.Micromachines · 2023Article
- A solution to the biophysical fractionation of extracellular vesicles: Acoustic Nanoscale Separation via Wave-pillar Excitation Resonance (ANSWER).Science advances · 2022Article
- Review
- A Label-Free Electrical Impedance Spectroscopy for Detection of Clusters of Extracellular Vesicles Based on Their Unique Dielectric Properties.Biosensors · 2022Article
- Fully Automated, Sample-to-Answer Leukocyte Functional Assessment Platform for Continuous Sepsis Monitoring via Microliters of Blood.ACS sensors · 2021Article
- Self-aligned sequential lateral field non-uniformities over channel depth for high throughput dielectrophoretic cell deflection.Lab on a chip · 2021Article
- High-throughput dynamical analysis of dielectrophoretic frequency dispersion of single cells based on deflected flow streamlines.Analytical and bioanalytical chemistry · 2020Article
- High-Sensitivity in Dielectrophoresis Separations.Micromachines · 2020Review
- Towards the directed evolution of protein materials.MRS communications · 2019Article
- Estimation of the physical properties of neurons and glial cells using dielectrophoresis crossover frequency.Journal of biological physics · 2016Article
- Dielectric model for Chinese hamster ovary cells obtained by dielectrophoresis cytometry.Biomicrofluidics · 2016Article
- Label-free isolation of a prostate cancer cell among blood cells and the single-cell measurement of drug accumulation using an integrated microfluidic chip.Biomicrofluidics · 2015Article
- Microfluidic blood cell sorting: now and beyond.Small (Weinheim an der Bergstrasse, Germany) · 2014Review
- Comprehensive analysis of human cells motion under an irrotational AC electric field in an electro-microfluidic chip.PloS one · 2014Article
- Advances in microfluidic cell separation and manipulation.Current opinion in chemical engineering · 2013Article
- Microfluidic genome-wide profiling of intrinsic electrical properties in Saccharomyces cerevisiae.Lab on a chip · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Separations can be broadly categorized as preparative, where the objective is to extract purified quantities of a sample from a complex mixture, or analytic, where the goal is to determine and quantify the contents of the original mixture. Here we demonstrate the application of a new microfluidic separation method, isodielectric separation (IDS), to a range of analytic separations involving cells and particles spanning several orders of magnitude in volume and electrical conductivity. In IDS, cells are dielectrophoretically concentrated to the region along an electrical conductivity gradient where their polarizability vanishes; by measuring this position--the isodielectric point (IDP)--as operating conditions such as the frequency and voltage of the applied electric field are varied, we are able to sort cells or particles with distinct IDPs while simultaneously characterizing their electrical properties. We apply this technique to measure the electrical properties of polystyrene microspheres, viable and nonviable cells of the budding yeast Saccharomyces cerevisiae , and murine pro B cells, including how these electrical properties vary with the electrical conductivity of the surrounding solvent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.