ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
The Flk1-myr::mCherry mouse as a useful reporter to characterize multiple aspects of ocular blood vessel development and disease.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 38 citations in OpenAlex.
- Fluorescent Labeling Methods for Brain Structure Research.Molecules (Basel, Switzerland) · 2026Review
- Longitudinal OCT and OCTA monitoring reveals accelerated regression of hyaloid vessels in retinal degeneration 10 (rd10) mice.Scientific reports · 2019Article
- Engineering the vasculature for islet transplantation.Acta biomaterialia · 2019Review
- Methods to label, image, and analyze the complex structural architectures of microvascular networks.Microcirculation (New York, N.Y. : 1994) · 2019Review
- Overview of the reporter genes and reporter mouse models.Animal models and experimental medicine · 2018Review
- Macrophages engulf endothelial cell membrane particles preceding pupillary membrane capillary regression.Developmental biology · 2015Article
- Simultaneous in vivo imaging of blood and lymphatic vessel growth in Prox1-GFP/Flk1::myr-mCherry mice.The FEBS journal · 2015Article
- Improved Angiogenesis in Response to Localized Delivery of Macrophage-Recruiting Molecules.PloS one · 2015Article
- Modes of Antigen Presentation by Lymph Node Stromal Cells and Their Immunological Implications.Frontiers in immunology · 2015Review
- Quantitative imaging of cell dynamics in mouse embryos using light-sheet microscopy.Development (Cambridge, England) · 2014Article
- In vivo analysis of hyaloid vasculature morphogenesis in zebrafish: A role for the lens in maturation and maintenance of the hyaloid.Developmental biology · 2014Article
- Sema3A maintains corneal avascularity during development by inhibiting Vegf induced angioblast migration.Developmental biology · 2014Article
- Recruitment of CD34(+) fibroblasts in tumor-associated reactive stroma: the reactive microvasculature hypothesis.The American journal of pathology · 2014Article
- Dynamic responses of endothelial cells to changes in blood flow during vascular remodeling of the mouse yolk sac.Development (Cambridge, England) · 2013Article
- Three-dimensional vasculature reconstruction of tumour microenvironment via local clustering and classification.Interface focus · 2013Article
- Immobilization of Cell-Adhesive Laminin Peptides in Degradable PEGDA Hydrogels Influences Endothelial Cell Tubulogenesis.BioResearch open access · 2013Article
- Obesity and the risk and detection of fetal malformations.Seminars in perinatology · 2012Review
- Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad.PLoS genetics · 2012Article
- Live imaging fluorescent proteins in early mouse embryos.Methods in enzymology · 2012Article
- Biomimetic hydrogels with immobilized ephrinA1 for therapeutic angiogenesis.Biomacromolecules · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The highly vascularized mouse eye is an excellent model system in which to elucidate the molecular genetic basis of blood vessel development and disease. However, the analysis of ocular vessel defects has traditionally been derived from fixed tissue, which fails to account for dynamic events such as blood flow and cell migration. To overcome the limitations of static analysis, tremendous advances in imaging technology and fluorescent protein reporter mouse lines now enable the direct visualization of developing cells in vivo. Here, we demonstrate that the Flk1-myr::mCherry transgenic mouse is an extremely useful live reporter with broad applicability to retinal, hyaloid, and choroid vascular research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.