ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Deficiency screen identifies a novel role for beta 2 tubulin in salivary gland and myoblast migration in the Drosophila embryo.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 citing papers in PubMed, 10 citations in OpenAlex.
- Article
- Control of seminal fluid protein expression via regulatory hubs inProceedings. Biological sciences · 2018Article
- Drosophila KASH-domain protein Klarsicht regulates microtubule stability and integrin receptor localization during collective cell migration.Developmental biology · 2015Article
- Receptor guanylyl cyclase Gyc76C is required for invagination, collective migration and lumen shape in the Drosophila embryonic salivary gland.Biology open · 2013Article
- Receptor-type guanylyl cyclase Gyc76C is required for development of the Drosophila embryonic somatic muscle.Biology open · 2012Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila embryonic salivary gland is an epithelial organ formed by the coordinated invagination and migration of primordial cells. To identify genes that regulate gland migration we performed a deficiency screen of the third chromosome. Here, we report on the analysis of the beta 2 tubulin isoform (beta2t) that maps at 85D15. We show that, in beta2t mutant embryos, salivary glands did not complete their posterior migration and that migration of fusion competent myoblasts and longitudinal visceral muscle founder cells between the gland and circular visceral mesoderm was delayed. We also demonstrate that gland migration defects correlate with reduced betaPS and alphaPS2 integrin expression in the surrounding mesoderm and that beta2t genetically interacts with genes encoding integrin alphaPS1 and alphaPS2 subunits. Our studies reveal for the first time that beta2t is expressed in embryogenesis and that beta2t plays an important role in salivary gland and myoblast migration, possibly through proper regulation of integrin adhesion proteins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.