ReviewMedical mycology2009
Aspergillus fumigatus metabolism: clues to mechanisms of in vivo fungal growth and virulence.
Review in Medical mycology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 65 citations in OpenAlex.
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- Fungal pathogens and symbionts: Living off the fat of the land.PLoS pathogens · 2024Review
- Dynamic full-field optical coherence tomography for live-cell imaging and growth-phase monitoring inFrontiers in cellular and infection microbiology · 2023Article
- Benzyl isothiocyanate improves the prognosis ofFrontiers in microbiology · 2023Article
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- Extensive non-coding sequence divergence between the major human pathogenFrontiers in fungal biology · 2022Article
- The Peroxiredoxin Asp f3 Acts as Redox Sensor inGenes · 2021Article
- Study of the Effect of Nutrient Environment on the Biological Characteristics ofJournal of ophthalmology · 2021Article
- Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity.Nature communications · 2020Article
- Caenorhabditis elegans as a model animal for investigating fungal pathogenesis.Medical microbiology and immunology · 2020Review
- The mysterious desert dwellers: Coccidioides immitis and Coccidioides posadasii, causative fungal agents of coccidioidomycosis.Virulence · 2019Review
- How Environmental Fungi Cause a Range of Clinical Outcomes in Susceptible Hosts.Journal of molecular biology · 2019Review
- Nutritional Heterogeneity AmongFrontiers in microbiology · 2019Article
- TargetingFrontiers in microbiology · 2019Article
- Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression.PLoS pathogens · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Aspergillus fumigatus is a saprophytic fungus commonly found in soil and compost piles. In immunocompromised patients it takes on a sinister form as a potentially lethal opportunistic human pathogen. We currently have a limited understanding of the in vivo growth mechanisms used by A. fumigatus during invasive pulmonary aspergillosis (IPA). The ability of A. fumigatus to adapt to various microenvironments encountered during growth in the human host may explain why A. fumigatus is the most frequently occurring opportunistic pathogenic mold. The transcriptional and metabolic responses to changing microenvironments found in the mammalian lung require the activation of pathways implicated in resistance to unique stresses. Thus, the production of primary metabolites in vivo may give clues to the critical pathways used by A. fumigatus to cause disease in human hosts. We recently have identified primary metabolites in the mammalian lung typically associated with fungal growth under hypoxic environments suggesting that A. fumigatus may encounter low oxygen tensions during IPA. These and other studies on A. fumigatus metabolism are the focus of this review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.