ReviewJournal of mammary gland biology and neoplasia2009
Radiation resistance of breast cancer stem cells: understanding the clinical framework.
Review in Journal of mammary gland biology and neoplasia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 50 citations in OpenAlex.
- Thrombospondin 1 Promotes Cytoskeleton Remodeling, Dedifferentiation, and Pulmonary Metastasis through ITGA1 and ITGA6 in Osteosarcoma.International journal of biological sciences · 2025Article
- Raman Spectroscopy Revealed Cell Passage-Dependent Distinct Biochemical Alterations in Radiation-Resistant Breast Cancer Cells.ACS omega · 2023Article
- Counteracting Chemoresistance with Metformin in Breast Cancers: Targeting Cancer Stem Cells.Cancers · 2020Review
- Inhibitor of DNA binding 1 (Id1) mediates stemness of colorectal cancer cells through the Id1-c-Myc-PLAC8 axis via the Wnt/β-catenin and Shh signaling pathways.Cancer management and research · 2019Article
- MicroRNAs, Hypoxia and the Stem-Like State as Contributors to Cancer Aggressiveness.Frontiers in genetics · 2019Review
- Role of Akt signaling in resistance to DNA-targeted therapy.World journal of clinical oncology · 2016Review
- Targeting CXCR1 on breast cancer stem cells: signaling pathways and clinical application modelling.Oncotarget · 2015Article
- Immunobiology and signaling pathways of cancer stem cells: implication for cancer therapy.Cytotechnology · 2015Article
- CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance.Molecular cancer therapeutics · 2015Article
- Radiobiological characteristics of cancer stem cells from esophageal cancer cell lines.World journal of gastroenterology · 2014Article
- Mitochondrial MKP1 is a target for therapy-resistant HER2-positive breast cancer cells.Cancer research · 2014Article
- miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13.Nature communications · 2014Article
- MicroRNAs and cancer stem cells: the sword and the shield.Oncogene · 2014Review
- Immunotherapy of radioresistant mammary tumors with early metastasis using molecular chaperone vaccines combined with ionizing radiation.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Basal/HER2 breast carcinomas: integrating molecular taxonomy with cancer stem cell dynamics to predict primary resistance to trastuzumab (Herceptin).Cell cycle (Georgetown, Tex.) · 2013Article
- Article
- Epithelial-to-mesenchymal transition (EMT) confers primary resistance to trastuzumab (Herceptin).Cell cycle (Georgetown, Tex.) · 2012Article
- Basal-like breast cancer stem cells are sensitive to anti-DR5 mediated cytotoxicity.Breast cancer research and treatment · 2012Article
- Ionizing radiation induces stemness in cancer cells.PloS one · 2012Article
- The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Meta-analyses of tens of thousands of women treated with radiation as a component of their breast cancer treatment have shown that radiation improves overall survival from breast cancer in women with early stage and advanced disease. However, data suggest that breast cancer stem/progenitor cells can be enriched after radiation and that breast cancer stem/progenitor clonogens are particularly resistant to radiation. Potentially resistant breast cancer stem/progenitor populations appear to be over-represented in estrogen receptor negative breast cancer and indeed, clinically these cancers are more resistant to radiation than estrogen receptor positive breast cancers. Emerging pre-clinical data suggest that targeting cancer stem/progenitor survival pathways may lead to effective radiosensitization in subgroups of patients with resistant disease. Herein, preclinical studies are reviewed in the context of the clinical framework.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.