ArticleClinical oral investigations2009
Gene expression profiles of dental follicle cells before and after osteogenic differentiation in vitro.
Article in Clinical oral investigations, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 64 citations in OpenAlex.
- Effect of micro-osteoperforations on the gene expression profile of the periodontal ligament of orthodontically moved human teeth.Clinical oral investigations · 2022Trial
- Genome-wide association study of periodontitis severity and progression.Journal of periodontology · 2026Article
- Article
- Evaluation of Current Studies to Elucidate Processes in Dental Follicle Cells Driving Osteogenic Differentiation.Biomedicines · 2023Review
- Mechanisms during Osteogenic Differentiation in Human Dental Follicle Cells.International journal of molecular sciences · 2022Review
- High endogenous expression of parathyroid hormone-related protein (PTHrP) supports osteogenic differentiation in human dental follicle cells.Histochemistry and cell biology · 2020Article
- Soluble silica stimulates osteogenic differentiation and gap junction communication in human dental follicle cells.Scientific reports · 2020Article
- Adipogenesis, Osteogenesis, and Chondrogenesis of Human Mesenchymal Stem/Stromal Cells: A Comparative Transcriptome Approach.Frontiers in cell and developmental biology · 2020Review
- Dickkopf-related protein 3 negatively regulates the osteogenic differentiation of rat dental follicle cells.Molecular medicine reports · 2017Article
- Transcription factor ZNF25 is associated with osteoblast differentiation of human skeletal stem cells.BMC genomics · 2016Article
- The extracellular concentration of osteocalcin decreased in dental follicle cell cultures during biomineralization.Cytotechnology · 2016Article
- Comparison of Stemness and Gene Expression between Gingiva and Dental Follicles in Children.Stem cells international · 2016Article
- Evaluation of implant-materials as cell carriers for dental stem cells under in vitro conditions.International journal of implant dentistry · 2015Article
- Mapping the global mRNA transcriptome during development of the murine first molar.Frontiers in genetics · 2015Article
- Epigenetic marks define the lineage and differentiation potential of two distinct neural crest-derived intermediate odontogenic progenitor populations.Stem cells and development · 2013Article
- GWAS of dental caries patterns in the permanent dentition.Journal of dental research · 2013Article
- Article
- The transcription factor DLX3 regulates the osteogenic differentiation of human dental follicle precursor cells.Stem cells and development · 2012Article
- Promise of periodontal ligament stem cells in regeneration of periodontium.Stem cell research & therapy · 2011Article
- Human tooth germ stem cell response to calcium-silicate based endodontic cements.Journal of applied oral science : revista FOBArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, osteogenic precursor cells were isolated from human dental follicles, which differentiate into cementoblast- or osteoblast-like cells under in vitro conditions after the induction with dexamethasone or insulin. However, mechanisms for osteogenic differentiation are not understood in detail. In a previous study, real-time RT-PCR results demonstrated molecular mechanisms in dental follicle cells (DFCs) during osteogenic differentiation that are different from those in bone-marrow-derived mesenchymal stem cells. We analysed gene expression profiles in DFCs before and after osteogenic differentiation with the Affymetrix GeneChip(R) Human Gene 1.0 ST Array. Transcripts of 98 genes were up-regulated after differentiation. These genes could be clustered into subcategories such as cell differentiation, cell morphogenesis, and skeletal development. Osteoblast-specific transcription factors like osterix and runx2 were constitutively expressed in differentiated DFCs. In contrast, the transcription factor ZBTB16, which promotes the osteoblastic differentiation of mesenchymal stem cells as an up-stream regulator of runx2, was differentially expressed after differentiation. Transcription factors NR4A3, KLF9 and TSC22D3, involved in the regulation of cellular development, were up-regulated as well. In conclusion, we present the first transcriptome of human DFCs before and after osteogenic differentiation. This study sheds new light on the complex mechanism of osteogenic differentiation in DFCs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.