ArticlePflugers Archiv : European journal of physiology2009
Proliferation of neuronal progenitor cells and neuronal differentiation in the hypothalamus are enhanced in heat-acclimated rats.
Article in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- The Adult Neurogenesis Theory of Alzheimer's Disease Predicts Where Tauopathy Develops in the Brain.International journal of molecular sciences · 2026Review
- Thermal challenge and food intake: Mutual regulatory mechanisms.Neural regeneration research · 2026Article
- Prenatal acoustic communication triggers adaptive vascular programming in the developing avian brain.The Journal of experimental biology · 2026Article
- Neural Progenitor Cells and the Hypothalamus.Cells · 2023Review
- The Adult Neurogenesis Theory of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Human temperature regulation under heat stress in health, disease, and injury.Physiological reviews · 2022Review
- Chronic Administration of Thymoquinone Enhances Adult Hippocampal Neurogenesis and Improves Memory in Rats Via Regulating the BDNF Signaling Pathway.Neurochemical research · 2022Article
- Review
- Salivary Immunoglobulin A Secretion and Polymeric Ig Receptor Expression in the Submandibular Glands Are Enhanced in Heat-Acclimated Rats.International journal of molecular sciences · 2020Article
- Intermittent fasting increases adult hippocampal neurogenesis.Brain and behavior · 2020Article
- The parental brain and behavior: A target for endocrine disruption.Frontiers in neuroendocrinology · 2019Review
- Thermal Manipulation During Embryogenesis Impacts H3K4me3 and H3K27me3 Histone Marks in Chicken Hypothalamus.Frontiers in genetics · 2019Article
- Regulation and function of neurogenesis in the adult mammalian hypothalamus.Progress in neurobiology · 2018Review
- Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands.FEBS open bio · 2018Article
- Heat Shock Proteins Regulatory Role in Neurodevelopment.Frontiers in neuroscience · 2018Review
- Hypothalamic Neurogenesis as an Adaptive Metabolic Mechanism.Frontiers in neuroscience · 2017Review
- Neural progenitor cell proliferation in the hypothalamus is involved in acquired heat tolerance in long-term heat-acclimated rats.PloS one · 2017Article
- Direct exposure to mild heat promotes proliferation and neuronal differentiation of neural stem/progenitor cells in vitro.PloS one · 2017Article
- Noncanonical Sites of Adult Neurogenesis in the Mammalian Brain.Cold Spring Harbor perspectives in biology · 2015Review
- Neuroprotection after traumatic brain injury in heat-acclimated mice involves induced neurogenesis and activation of angiotensin receptor type 2 signaling.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Male Wistar rats, initially maintained at an ambient temperature (T (a)) of 24 degrees C, were subjected to a constant high T (a) of 32 degrees C (HE) or were constantly kept at 24 degrees C (controls, CN). Bromodeoxyuridine (BrdU) was intraperitoneally injected daily for five consecutive days after commencing heat exposure. On the 6th, 13th, 23rd, 33rd, 43rd, and 53rd day of heat exposure, rats' brains were removed. Immunohistochemical analysis showed that the numbers of BrdU-positive cells in the hypothalamus of HE were significantly and consistently greater than those of CN. In HE, the number of BrdU-positive cells double-stained by a mature neuron marker increased abruptly after 33 days of heat exposure by about seven times. This was not the case in CN. The results suggest that heat exposure facilitates proliferation of neuronal progenitor cells in the hypothalamus and promotes differentiation to neurons, which might have certain relation to establishing long-term heat acclimation in rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.