ArticlePaediatrics & child health2008
The ethics of using innovative therapies in the care of children.
Article in Paediatrics & child health, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Hoping Against Hope: Ethical Considerations when Trying Unproven Treatments for Seriously Ill Children.Asian bioethics review · 2025Article
- Ethics codes and use of new and innovative drugs.British journal of clinical pharmacology · 2019Review
- Research as a Standard of Care in the PICU.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2016Review
- Prospects of risk-sharing agreements for innovative therapies in a context of deficit spending in bulgaria.Frontiers in public health · 2015Article
- Children who 'grow up' in hospital: Inpatient stays of six months or longer.Paediatrics & child health · 2014Article
- Severe systemic candidiasis following immunomodulation therapy in in vitro fertilisation-embryo transfer (IVF-ET).BMJ case reports · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An innovative therapy is a newly introduced or modified therapy with unproven effect or side effect, and is undertaken in the best interest of the patient. The ethical use of innovative therapies has been controversial. In paediatrics, the conflict between withholding potential rescue therapy and protecting a vulnerable population's rights and welfare must be considered. Therefore, it is necessary to ensure that this innovation is conducted within an ethical framework that recognizes that the therapy is not standard. This should integrate the patient's autonomy, the role of the institution, professional consensus and innovation evaluation. Innovative therapy represents a justifiable departure from inferior conventional therapy in the absence of an accepted standard therapy. Innovation shares with research its experimental nature, but differs from research in its goal and context that exempts innovative therapy from direct governance by research ethics board. Innovative therapy is part of the continuum of hypothesis generation in the advancement of medical knowledge, and its evaluation is a transforming point for clinical research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.