ReviewNature reviews. Microbiology2009
The role of predictive modelling in rationally re-engineering biological systems.
Review in Nature reviews. Microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Epistemology of synthetic biology: a new theoretical framework based on its potential objects and objectives.Frontiers in bioengineering and biotechnology · 2023Article
- Unraveling interactions in microbial communities - from co-cultures to microbiomes.Journal of microbiology (Seoul, Korea) · 2015Review
- Opportunities for synthetic biology in antibiotics: expanding glycopeptide chemical diversity.ACS synthetic biology · 2015Review
- RobOKoD: microbial strain design for (over)production of target compounds.Frontiers in cell and developmental biology · 2015Article
- Synthetic biology approaches to improve biocatalyst identification in metagenomic library screening.Microbial biotechnology · 2015Review
- Biosensor architectures for high-fidelity reporting of cellular signaling.Biophysical journal · 2014Article
- Identification of alterations in the Jacobian of biochemical reaction networks from steady state covariance data at two conditions.Journal of mathematical biology · 2014Article
- Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.Archives of toxicology · 2013Review
- Engineering ecosystems and synthetic ecologies.Molecular bioSystems · 2012Review
- Regulatory consequences of gene translocation in bacteria.Nucleic acids research · 2012Article
- Computational design of genomic transcriptional networks with adaptation to varying environments.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Reverse engineering systems models of regulation: discovery, prediction and mechanisms.Current opinion in biotechnology · 2012Review
- Programming an in vitro DNA oscillator using a molecular networking strategy.Molecular systems biology · 2011Article
- Integrative analysis of large scale expression profiles reveals core transcriptional response and coordination between multiple cellular processes in a cyanobacterium.BMC systems biology · 2010Article
- Large scale physiological readjustment during growth enables rapid, comprehensive and inexpensive systems analysis.BMC systems biology · 2010Article
- Microfluidic devices for measuring gene network dynamics in single cells.Nature reviews. Genetics · 2009Review
- Adaptation of cells to new environments.Wiley interdisciplinary reviews. Systems biology and medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Technologies to synthesize and transplant a complete genome into a cell have opened limitless potential to redesign organisms for complex, specialized tasks. However, large-scale re-engineering of a biological circuit will require systems-level optimization that will come from a deep understanding of operational relationships among all the constituent parts of a cell. The integrated framework necessary for conducting such complex bioengineering requires the convergence of systems and synthetic biology. Here, we review the status of these rapidly developing interdisciplinary fields of biology and provide a perspective on plausible venues for their merger.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.