ArticleJournal of lipid research2009
Hepatic SR-BI, not endothelial lipase, expression determines biliary cholesterol secretion in mice.
Article in Journal of lipid research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Current Understanding of the Relationship of HDL Composition, Structure and Function to Their Cardioprotective Properties in Chronic Kidney Disease.Biomolecules · 2020Review
- Article
- FXR activation promotes intestinal cholesterol excretion and attenuates hyperlipidemia in SR-B1-deficient mice fed a high-fat and high-cholesterol diet.Physiological reports · 2020Article
- PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor.ACS medicinal chemistry letters · 2018Article
- HDL Cholesterol Metabolism and the Risk of CHD: New Insights from Human Genetics.Current cardiology reports · 2017Review
- High density lipoprotein (HDL) particles from end-stage renal disease patients are defective in promoting reverse cholesterol transport.Scientific reports · 2017Article
- SR-BI: Linking Cholesterol and Lipoprotein Metabolism with Breast and Prostate Cancer.Frontiers in pharmacology · 2016Review
- GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice.Metabolism: clinical and experimental · 2015Article
- Differential basolateral-apical distribution of scavenger receptor, class B, type I in cultured cells and the liver.Histochemistry and cell biology · 2014Article
- Monogenic causes of elevated HDL cholesterol and implications for development of new therapeutics.Clinical lipidology · 2013Article
- Cooperation between hepatic cholesteryl ester hydrolase and scavenger receptor BI for hydrolysis of HDL-CE.Journal of lipid research · 2013Article
- Intestinal SR-BI does not impact cholesterol absorption or transintestinal cholesterol efflux in mice.Journal of lipid research · 2013Article
- Modulation of lipid metabolism with the overexpression of NPC1L1 in mouse liver.Journal of lipid research · 2012Article
- miR-33 controls the expression of biliary transporters, and mediates statin- and diet-induced hepatotoxicity.EMBO molecular medicine · 2012Article
- The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulation.The Journal of biological chemistry · 2012Article
- Dietary resveratrol increases the expression of hepatic 7α-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice.Lipids in health and disease · 2012Article
- ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma.Journal of lipid research · 2012Article
- Regulation of reverse cholesterol transport - a comprehensive appraisal of available animal studies.Nutrition & metabolism · 2012Article
- Differential roles of cysteine residues in the cellular trafficking, dimerization, and function of the high-density lipoprotein receptor, SR-BI.Biochemistry · 2011Article
- Role of hepatic lipase and endothelial lipase in high-density lipoprotein-mediated reverse cholesterol transport.Current atherosclerosis reports · 2011Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High density lipoprotein cholesterol is thought to represent a preferred source of sterols secreted into bile following hepatic uptake by scavenger receptor class B type I (SR-BI). The present study aimed to determine the metabolic effects of an endothelial lipase (EL)-mediated stimulation of HDL cholesterol uptake on liver lipid metabolism and biliary cholesterol secretion in wild-type, SR-BI knockout, and SR-BI overexpressing mice. In each model, injection of an EL expressing adenovirus decreased plasma HDL cholesterol (P < 0.001) whereas hepatic cholesterol content increased (P < 0.05), translating into decreased expression of sterol-regulatory element binding protein 2 (SREBP2) and its target genes HMG-CoA reductase and LDL receptor (each P < 0.01). Biliary cholesterol secretion was dependent on hepatic SR-BI expression, being decreased in SR-BI knockouts (P < 0.001) and increased following hepatic SR-BI overexpression (P < 0.001). However, in each model, biliary secretion of cholesterol, bile acids, and phospholipids as well as fecal bile acid and neutral sterol content, remained unchanged in response to EL overexpression. Importantly, hepatic ABCG5/G8 expression did not correlate with biliary cholesterol secretion rates under these conditions. These results demonstrate that an acute decrease of plasma HDL cholesterol levels by overexpressing EL increases hepatic cholesterol content but leaves biliary sterol secretion unaltered. Instead, biliary cholesterol secretion rates are related to the hepatic expression level of SR-BI. These data stress the importance of SR-BI for biliary cholesterol secretion and might have relevance for concepts of reverse cholesterol transport.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.