ArticleJournal of bacteriology2009
Phylogeography of Francisella tularensis: global expansion of a highly fit clone.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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100 citing papers in PubMed.
- A field-deployable high-resolution SNP genotyping platform for rapid surveillance ofVirulence · 2026Article
- Detection of Francisellaceae and the differentiation of main European F. tularensis ssp. holarctica strains (Clades) by new designed qPCR assays.BMC microbiology · 2025Article
- A patient with long-term diabetes dies following infection withInfectious diseases & immunity · 2025Article
- Virulence and genome analysis of three historicalFrontiers in cellular and infection microbiology · 2025Article
- Reduced representation approaches produce similar results to whole genome sequencing for some common phylogeographic analyses.PloS one · 2023Article
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- Ulceroglandular form of tularemia after squirrel bite: a case report.Journal of medical case reports · 2022Article
- Tularemia Outbreaks in Spain from 2007 to 2020 in Humans and Domestic and Wild Animals.Pathogens (Basel, Switzerland) · 2021Article
- Genetic diversity of Francisella tularensis subsp. holarctica in Kazakhstan.PLoS neglected tropical diseases · 2021Article
- Reorganized Genomic Taxonomy ofMicroorganisms · 2021Article
- Development, Phenotypic Characterization and Genomic Analysis of aFrontiers in microbiology · 2021Article
- Genotyping ofMicroorganisms · 2020Article
- Virulence ofMicroorganisms · 2020Article
- Genetic Traces of theMicroorganisms · 2020Article
- Outbreak of Tularemia in a Group of Hunters in Germany in 2018-Kinetics of Antibody and Cytokine Responses.Microorganisms · 2020Article
- Tularemia Goes West: Epidemiology of an Emerging Infection in Austria.Microorganisms · 2020Review
- Differences in Blood-derivedMicroorganisms · 2020Article
- Review
- Using affinity propagation clustering for identifying bacterial clades and subclades with whole-genome sequences of Francisella tularensis.PLoS neglected tropical diseases · 2020Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Francisella tularensis contains several highly pathogenic subspecies, including Francisella tularensis subsp. holarctica, whose distribution is circumpolar in the northern hemisphere. The phylogeography of these subspecies and their subclades was examined using whole-genome single nucleotide polymorphism (SNP) analysis, high-density microarray SNP genotyping, and real-time-PCR-based canonical SNP (canSNP) assays. Almost 30,000 SNPs were identified among 13 whole genomes for phylogenetic analysis. We selected 1,655 SNPs to genotype 95 isolates on a high-density microarray platform. Finally, 23 clade- and subclade-specific canSNPs were identified and used to genotype 496 isolates to establish global geographic genetic patterns. We confirm previous findings concerning the four subspecies and two Francisella tularensis subsp. tularensis subpopulations and identify additional structure within these groups. We identify 11 subclades within F. tularensis subsp. holarctica, including a new, genetically distinct subclade that appears intermediate between Japanese F. tularensis subsp. holarctica isolates and the common F. tularensis subsp. holarctica isolates associated with the radiation event (the B radiation) wherein this subspecies spread throughout the northern hemisphere. Phylogenetic analyses suggest a North American origin for this B-radiation clade and multiple dispersal events between North America and Eurasia. These findings indicate a complex transmission history for F. tularensis subsp. holarctica.
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