ArticleBiochemical and biophysical research communications2009
Transcriptional activation by TLX1/HOX11 involves Gro/TLE corepressors.
Article in Biochemical and biophysical research communications, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- TLE4 is a repressor of the oncogenic activity of TLX3 in T-cell acute lymphoblastic leukemia.Leukemia · 2025Article
- Analyses of binding partners and functional domains for the developmentally essential protein Hmx3a/HMX3.Scientific reports · 2023Article
- Amplification of the PLAG-family genes-PLAGL1 and PLAGL2-is a key feature of the novel tumor type CNS embryonal tumor with PLAGL amplification.Acta neuropathologica · 2023Article
- Identification of key genes involved in the recurrence of glioblastoma multiforme using weighted gene co-expression network analysis and differential expression analysis.Bioengineered · 2021Article
- Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord.Frontiers in cell and developmental biology · 2021Article
- Deregulated expression of NKL homeobox genes in T-cell lymphomas.Oncotarget · 2019Article
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- NKL homeobox gene activities in hematopoietic stem cells, T-cell development and T-cell leukemia.PloS one · 2017Article
- FHL1C induces apoptosis in Notch1-dependent T-ALL cells through an interaction with RBP-J.BMC cancer · 2014Article
- Barx2 and Pax7 have antagonistic functions in regulation of wnt signaling and satellite cell differentiation.Stem cells (Dayton, Ohio) · 2014Article
- The DN2 Myeloid-T (DN2mt) Progenitor is a Target Cell for Leukemic Transformation by the TLX1 Oncogene.Journal of bone marrow research · 2013Article
- NKL homeobox genes in leukemia.Leukemia · 2012Review
- Transcriptional activation of prostate specific homeobox gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL).PloS one · 2012Article
- Lentiviral fluorescent protein expression vectors for biotinylation proteomics.Methods in molecular biology (Clifton, N.J.) · 2011Article
- Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1.Molecular cancer · 2010Article
- TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells.Molecular cancer · 2010Article
- Hematopoietic immortalizing function of the NKL-subclass homeobox gene TLX1.Genes, chromosomes & cancer · 2010Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The role of Groucho/transducin-like Enhancer of split (Gro/TLE) family members as corepressors of transcription is well documented. TLX1 is a homeodomain transcription factor involved in splenogenesis and neuron formation, and its aberrant expression gives rise to T-cell acute lymphoblastic leukemia. We demonstrate by glutathione-S-transferase pull-down assays, in vivo biotinylation tagging and confocal laser microscopy that TLX1 interacts with TLE1 via an Eh1-like motif. Paradoxically, we found that this motif is essential for optimal transcriptional activation of two TLX1 target genes, Aldh1a1 and Fhl1. Using a well characterized target of the Hairy/Enhancer of split 1 (HES1).TLE1 repressor complex, the ASCL1 gene, we show that TLX1 counteraction of ASCL1 repression by HES1 in SK-N-BE(2) neuroblastoma cells is associated with dismissal of TLE1 from the ASCL1 promoter and requires the Eh1-like motif for maximal effect. Collectively, these results indicate that TLX1-mediated target gene activation can occur in part via derepression strategies involving Gro/TLE corepressors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.