ArticleHelicobacter2008
Helicobacter pylori and gastroesophageal reflux disease: a case-control study.
Article in Helicobacter, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- The Aging Stomach: Clinical Implications ofInternational journal of molecular sciences · 2024Review
- Risk of Reflux-Related Symptoms and Reflux Esophagitis afterJournal of clinical medicine · 2021Article
- Helicobacter pylori Related Diseases and Osteoporotic Fractures (Narrative Review).Journal of clinical medicine · 2020Review
- Gastroesophageal reflux disease in a typical African population: a symptom-based multicenter study.BMC gastroenterology · 2020Observational
- The Influences of Visceral Fat Area on the Sites of Esophageal Mucosal Breaks in Subjects with Gastroesophageal Reflux Diseases.Gastroenterology research and practice · 2019Article
- Prevalence of cytotoxin-associated genes ofGastroenterology and hepatology from bed to bench · 2017Article
- The Gastric Mucosa from Patients Infected with CagA+ or VacA+ Helicobacter pylori Has a Lower Level of Dual Oxidase-2 Expression than Uninfected or Infected with CagA-/VacA- H. pylori.Digestive diseases and sciences · 2016Article
- Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia.World journal of gastroenterology · 2016Article
- Ghrelin and Leptin Have a Complex Relationship with Risk of Barrett's Esophagus.Digestive diseases and sciences · 2016Article
- Association of medications for lifestyle-related diseases with reflux esophagitis.Therapeutics and clinical risk management · 2016Article
- A review of the epidemiology of Barrett's oesophagus and oesophageal adenocarcinoma.Best practice & research. Clinical gastroenterology · 2015Review
- Helicobacter pylori Infection in Gastroesophageal Reflux Disease in the Asian Countries.Gastroenterology research and practice · 2015Review
- Helicobacter pylori infection in older people.World journal of gastroenterology · 2014Review
- Irritable bowel syndrome is associated with gastroesophageal reflux symptom but not erosive esophagitis.Journal of neurogastroenterology and motility · 2013Article
- Vegetarianism as a protective factor for reflux esophagitis: a retrospective, cross-sectional study between Buddhist priests and general population.Digestive diseases and sciences · 2013Article
- Prognostic value of Helicobacter pylori sinonasal colonization for efficacy of endoscopic sinus surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2012Article
- Helicobacter pylori Eradication Therapy: Current Availabilities.ISRN gastroenterology · 2012Article
- Helicobacter pylori: Eradication or Preservation.F1000 medicine reports · 2012Article
- Helicobacter pylori Serology Inversely Correlated With the Risk and Severity of Reflux Esophagitis in Helicobacter pylori Endemic Area: A Matched Case-Control Study of 5,616 Health Check-Up Koreans.Journal of neurogastroenterology and motility · 2011Article
- Helicobacter pylori Has an Inverse Relationship With Severity of Reflux Esophagitis.Journal of neurogastroenterology and motility · 2011Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundGastric colonization with Helicobacter pylori is a proposed protective factor against gastroesophageal reflux disease (GERD), but little population-based data exist and other data conflict.
methodsWe conducted a case-control study within the membership of a large integrated health-care system that compared GERD-free subjects with two groups: subjects with a physician-assigned GERD diagnosis and randomly selected members with self-described weekly GERD symptoms. Subjects completed interviews, GERD questionnaires, and antibody testing for H. pylori and its cagA protein.
resultsSerologic data were available for 301 physician-assigned GERD patients, 81 general membership subjects with GERD symptoms, and 175 general membership subjects without GERD symptoms. Physician-assigned GERD patients were less likely to have H. pylori antibodies than GERD-free member controls (odds ratio (OR) = 0.27, 95% confidence interval (CI) 0.15-0.47); there was also an inverse association between H. pylori and GERD symptom severity (OR = 0.18, 95% CI 0.08-0.41; severe or very severe symptoms) and GERD frequency (OR = 0.18, 95% CI 0.09-0.38; for symptoms at least weekly). The association was stronger among persons with erosive GERD and was similar between H. pylori-positive subjects with and without cagA. There was no association among persons who were cagA positive, but H. pylori negative. Similar findings were found in analyses of the general membership with self-described GERD symptoms.
conclusionsH. pylori antibody status was inversely associated with a GERD diagnosis and GERD symptoms compared with a general membership population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.