ArticleJournal of the American Chemical Society2009
Photoinitiated destruction of composite porphyrin-protein polymersomes.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 67 citations in OpenAlex.
- Shape Transformation of Polymer Vesicles.Accounts of materials research · 2024Article
- Polymersome Poration and Rupture Mediated by Plasmonic Nanoparticles in Response to Single-Pulse Irradiation.Polymers · 2020Article
- Ruthenium-Crosslinked Hydrogels with Rapid, Visible-Light Degradation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018Article
- A simple method for the synthesis of porous polymeric vesicles and their application as MR contrast agents.Journal of materials chemistry. B · 2015Article
- Caging metal ions with visible light-responsive nanopolymersomes.Langmuir : the ACS journal of surfaces and colloids · 2015Article
- Exploiting endocytosis for nanomedicines.Cold Spring Harbor perspectives in biology · 2013Review
- Improved tumor targeting of polymer-based nanovesicles using polymer-lipid blends.Bioconjugate chemistry · 2011Article
- Sensing membrane stress with near IR-emissive porphyrins.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Recent trends in the tuning of polymersomes' membrane properties.The European physical journal. E, Soft matter · 2011Review
- NANOSCALE SELF-ASSEMBLY FOR DELIVERY OF THERAPEUTICS AND IMAGING AGENTS.Technology and innovation · 2011Article
- Two-photon microscopy of oxygen: polymersomes as probe carrier vehicles.The journal of physical chemistry. B · 2010Article
- Tunable leuko-polymersomes that adhere specifically to inflammatory markers.Langmuir : the ACS journal of surfaces and colloids · 2010Article
- A Generalized System for Photo-Responsive Membrane Rupture in Polymersomes.Advanced functional materials · 2010Article
- Modular synthesis of biodegradable diblock copolymers for designing functional polymersomes.Journal of the American Chemical Society · 2010Article
- Biodegradable Polymersomes for the Delivery of Gemcitabine to Panc-1 Cells.Journal of pharmaceuticsArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Bilayer vesicles assembled from amphiphilic diblock copolymers (polymersomes) adopt asymmetric structures when loaded with moderate concentrations (>or=1.5 mg/mL) of horse spleen ferritin (HSF) or its iron-free variant (HSAF). Incorporation of both ferritin and a zinc porphyrin dimer (PZn(2)) generates photoresponsive vesicles: irradiation with focused light of near-UV to near-IR wavelengths induces polymersome deformation and destruction on the minute time scale. To investigate this phenomenon, polymersomes were loaded with dye-labeled ferritin and PZn(2). Confocal microscopy identified BODIPY-FL-labeled ferritin at the membrane, whereas Cy3-labeled ferritin was found both at the membrane and throughout the aqueous core. Fluorescence recovery after photobleaching (FRAP) experiments confirmed that Cy3- and BODIPY-FL-labeled ferritin and PZn(2) exhibited slow diffusion at the membrane, consistent with membrane association. Furthermore, micropipette aspiration experiments revealed increased elastic moduli and altered bending rigidity in vesicles incorporating HSAF. Finally, a small molecule (biocytin) was encapsulated within the ferritin-PZn(2) vesicles and released upon exposure to light. These data indicate synergy between ferritin, whose membrane association lowers the barrier to deformation, and PZn(2), which embeds in the membrane, harvests light energy and produces local heating that may lead to membrane budding. This appears to be a general protein-polymer membrane phenomenon, as replacement of ferritin with bovine serum albumin or equine skeletal myoglobin resulted in vesicles with similar asymmetric morphology and photosensitivity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.