ArticleAmerican journal of surgery2009
Parenteral nutrition maintains pulmonary IgA antibody transport capacity, but not active transport, following injury.
Article in American journal of surgery, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- The effect of enteral stimulation on the immune response of the intestinal mucosa and its application in nutritional support.European journal of clinical nutrition · 2021Review
- B-lymphocyte-intrinsic and -extrinsic defects in secretory immunoglobulin A production in the neural crest-conditional deletion of endothelin receptor B model of Hirschsprung-associated enterocolitis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Gastrointestinal immune and microbiome changes during parenteral nutrition.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- Innate Mucosal Immune System Response of BALB/c vs C57BL/6 Mice to Injury in the Setting of Enteral and Parenteral Feeding.JPEN. Journal of parenteral and enteral nutrition · 2016Article
- The gastrointestinal immune system: Implications for the surgical patient.Current problems in surgery · 2016Review
- Gut Lymphocyte Phenotype Changes After Parenteral Nutrition and Neuropeptide Administration.Annals of surgery · 2015Article
- Bombesin improves adaptive immunity of the salivary gland during parenteral nutrition.JPEN. Journal of parenteral and enteral nutrition · 2015Article
- Cranberry proanthocyanidins improve intestinal sIgA during elemental enteral nutrition.JPEN. Journal of parenteral and enteral nutrition · 2014Article
- IL-25 improves IgA levels during parenteral nutrition through the JAK-STAT pathway.Annals of surgery · 2013Article
- Small intestine mucosal immune system response to injury and the impact of parenteral nutrition.Surgery · 2012Article
- Proteome analysis of bronchoalveolar lavage in pulmonary langerhans cell histiocytosis.Journal of clinical bioinformatics · 2011Article
- Nutrition and gut immunity.The Surgical clinics of North America · 2011Review
- Injury induces localized airway increases in pro-inflammatory cytokines in humans and mice.Surgical infections · 2011Article
- Proinflammatory cytokine surge after injury stimulates an airway immunoglobulin a increase.The Journal of trauma · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundParenteral nutrition (PN) increases post-trauma pneumonia versus enteral feeding. PN impairs murine immunoglobulin A (IgA) airway defenses and abrogates a normal IgA increase following injury. This work investigates the effect of type/route of nutrition on lung IgA and its transport protein, polymeric immunoglobulin receptor (pIgR), after injury.
methodsCatheterized mice were randomized to Chow or PN for 5 days and sacrificed without injury (Chow: n = 12; PN n = 11), or 8 hours after laparotomy + neck incisions (Chow-injury: n = 11, PN-injury: n = 13). Bronchoalveolar lavage (BAL) and lung IgA levels were analyzed by enzyme-linked immunosorbent assay (ELISA) and lung pIgR by Western blot.
resultsBAL IgA levels increased in Chow-injury versus PN-injury (P <.01) with no differences in pIgR. PN-injury tissue IgA levels decreased versus Chow (P <.01), Chow-injury (P <.01), and PN (P <.05).
conclusionsPN impairs the airway IgA response to injury but not due to impaired IgA transport capacity/pIgR level.
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Registered trials
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