ArticleNeurobiology of learning and memory2009
Intrahippocampal administration of an NMDA-receptor antagonist impairs spatial discrimination reversal learning in weanling rats.
Article in Neurobiology of learning and memory, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 48 citations in OpenAlex.
- Treadmill Exercise Training Ameliorates Apoptotic Cells and DNA Oxidation in the Cerebral Cortex of Rats Exposed to Chronic Ketamine Abuse.Addiction biology · 2025Article
- Reversal Training Discloses Gender Differences in a Spatial Memory Task in Humans.Brain sciences · 2023Article
- Rescue of sharp wave-ripples and prevention of network hyperexcitability in the ventral but not the dorsal hippocampus of a rat model of fragile X syndrome.Frontiers in cellular neuroscience · 2023Article
- The Impact of the Combined Administration of 1MeTIQ and MK-801 on Cell Viability, Oxidative Stress Markers, and Glutamate Release in the Rat Hippocampus.Neurotoxicity research · 2021Article
- NMDA receptors and the ontogeny of post-shock and retention freezing during contextual fear conditioning.Developmental psychobiology · 2020Article
- Place vs. Response Learning: History, Controversy, and Neurobiology.Frontiers in behavioral neuroscience · 2020Article
- Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol.Molecular medicine reports · 2018Article
- Granulocyte colony-stimulating factor significantly decreases density of hippocampal caspase 3-positive nuclei, thus ameliorating apoptosis-mediated damage, in a model of ischaemic neonatal brain injury.Interactive cardiovascular and thoracic surgery · 2017Article
- Antagonism of muscarinic acetylcholine receptors in medial prefrontal cortex disrupts the context preexposure facilitation effect.Neurobiology of learning and memory · 2017Article
- Impaired Spatial Memory and Enhanced Habit Memory in a Rat Model of Post-traumatic Stress Disorder.Frontiers in pharmacology · 2017Article
- Cholinergic mechanisms of the context preexposure facilitation effect in adolescent rats.Behavioral neuroscience · 2016Article
- Granulocyte colony stimulating factor reduces brain injury in a cardiopulmonary bypass-circulatory arrest model of ischemia in a newborn piglet.Neurochemical research · 2014Article
- A virtual reality task based on animal research - spatial learning and memory in patients after the first episode of schizophrenia.Frontiers in behavioral neuroscience · 2014Article
- Effect of exercise training on long-term potentiation and NMDA receptor channels in rats with cerebral infarction.Experimental and therapeutic medicine · 2013Article
- Determinants of novel object and location recognition during development.Behavioural brain research · 2013Article
- Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor.Behavioural brain research · 2013Article
- Septo-hippocampo-septal loop and memory formation.Basic and clinical neuroscience · 2013Review
- The role of glutamatergic pathway between septum and hippocampus in the memory formation.EXCLI journal · 2013Review
- Stress-induced impairments in prefrontal-mediated behaviors and the role of the N-methyl-D-aspartate receptor.Neuroscience · 2012Review
- Memory encoding in hippocampal ensembles is negatively influenced by cannabinoid CB1 receptors.Behavioural pharmacology · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Systemic administration of MK-801, an NMDA-receptor antagonist, impairs reversal learning in weanling rats [Chadman, K.K., Watson, D.J., & Stanton, M.E. (2006). NMDA-receptor antagonism impairs reversal learning in developing rats. Behavioral Neuroscience, 120(5), 1071-1083]. The brain systems responsible for this effect are not known in either adult or young animals. This study tested the hypothesis that hippocampal NMDA receptors are engaged in weanling-age rats during spatial discrimination reversal training in a T-maze. In Experiment 1, 26-day-old Long-Evans rats (P26) showed a dose-related impairment on this task following bilateral intrahippocampal administration of either 2.5 or 5.0microg MK-801 or saline vehicle during the reversal training phase only. In Experiment 2, P26 rats were trained on the same task, but received intrahippocampal MK-801 (2.5microg) during acquisition, reversal, both, or neither. MK-801 failed to impair acquisition, ruling out nonspecific "performance effects" of the drug. MK-801 impaired reversal irrespective of drug treatment during acquisition. NMDA-receptor antagonism in the hippocampus is sufficient to account for the previously reported effects of systemic MK-801 on reversal of T-maze position discrimination.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.