Evidence map›Paper›PMID 19248809›Full record

ReviewPharmacology & therapeutics2009

The therapeutic potential of novel cannabinoid receptors.

Faith R Kreitzer, Nephi Stella

Abstract readReview
In one paragraph

Review in Pharmacology & therapeutics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
7.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Cannabinoids for the Treatment of Dermatologic Conditions.JID innovations : skin science from molecules to population health · 2022
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Components of the cannabinoid system in the dorsal periaqueductal gray are related to resting heart rate.American journal of physiology. Regulatory, integrative and comparative physiology · 2016
    Article
  16. Article
  17. Article
  18. Review
  19. Emerging targets in lipid-based therapy.Biochemical pharmacology · 2013
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Faith R KreitzerDepartment of Pharmacology, University of Washington, Seattle, WA 98115-7280, USA.
Nephi Stella
University of Washington · US

Funding

Cannabinoid Signaling System in Microglial CellsR01DA014486 · NIDA · UNIVERSITY OF WASHINGTON · PI STELLA, NEPHI · 2001 to 2016
$4.2M
Novel CB ReceptorsR01DA021285 · NIDA · UNIVERSITY OF WASHINGTON · PI STELLA, NEPHI · 2007 to 2010
$1.2M
NIDA NIH HHS DA021285NIDA NIH HHS R01 DA014486NIDA NIH HHS R01 DA021285
6 · The paper itself

Abstract

Cannabinoids produce a plethora of biological effects, including the modulation of neuronal activity through the activation of CB(1) receptors and of immune responses through the activation of CB(2) receptors. The selective targeting of either of these two receptor subtypes has clear therapeutic value. Recent evidence indicates that some of the cannabinomimetic effects previously thought to be produced through CB(1) and/or CB(2) receptors, be they on neuronal activity, on the vasculature tone or immune responses, still persist despite the pharmacological blockade or genetic ablation of CB(1) and/or CB(2) receptors. This suggests that additional cannabinoid and cannabinoid-like receptors exist. Here we will review this evidence in the context of their therapeutic value and discuss their true belonging to the endocannabinoid signaling system.

Indexed as

Cannabinoid Receptor AgonistsCannabinoid Receptor AntagonistsAnimalsCannabinoid Receptor ModulatorsCannabinoidsHumansMiceReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, CannabinoidReceptors, G-Protein-CoupledReceptors, LysosphingolipidCannabinoid Receptor AgonistsCannabinoid Receptor AntagonistsCannabinoid Receptor ModulatorsCannabinoidsGPR55 protein, humanReceptor, Cannabinoid, CB1Receptor, Cannabinoid, CB2Receptors, CannabinoidReceptors, G-Protein-CoupledReceptors, Lysosphingolipid

Identifiers

PMID19248809
PMCPMC3685492
OpenAlexW2016322530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.