ArticleEuropean journal of immunology2009
DAP10 associates with Ly49 receptors but contributes minimally to their expression and function in vivo.
Article in European journal of immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Chronic NKG2D EngagementFrontiers in immunology · 2017Article
- Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.Blood · 2013Article
- The ly49 gene family. A brief guide to the nomenclature, genetics, and role in intracellular infection.Frontiers in immunology · 2013Article
- Article
- Unifying concepts of MHC-dependent natural killer cell education.Trends in immunology · 2011Review
- Distinct MHC class I-dependent NK cell-activating receptors control cytomegalovirus infection in different mouse strains.The Journal of experimental medicine · 2011Article
- Activation receptor-induced tolerance of mature NK cells in vivo requires signaling through the receptor and is reversible.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Interactions of NK cell receptor KIR3DL1*004 with chaperones and conformation-specific antibody reveal a functional folded state as well as predominant intracellular retention.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Current perspectives of natural killer cell education by MHC class I molecules.Nature reviews. Immunology · 2010Review
- Immune memory redefined: characterizing the longevity of natural killer cells.Immunological reviews · 2010Review
- TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.Science signaling · 2010Article
- The expanding roles of ITAM adapters FcRgamma and DAP12 in myeloid cells.Immunological reviews · 2009Review
- Evidence for high bi-allelic expression of activating Ly49 receptors.Nucleic acids research · 2009Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
NK cells recognize target cells through activating receptors, many of which rely on the transmembrane adaptors DAP10, DAP12 and FcR-gamma to deliver intracellular signals. Because these adaptors initiate distinct signaling pathways, they dictate the type of response mediated by receptor engagement. DAP10, for example, primarily triggers cytotoxicity, whereas DAP12 induces both cytotoxicity and IFN-gamma secretion. In mice, NKG2D signals through both DAP10 and DAP12, which broadens and modulates the type of response engendered by encounter with ligand. Although initial studies indicated that Ly49H and Ly49D recruit only DAP12, a recent report suggested that they also associate with DAP10. We asked whether this association occurs and is functionally significant under physiologic conditions. Our data demonstrate that DAP10 does associate with Ly49H and Ly49D in primary NK cells. While this association contributes slightly to cell surface expression of both receptors, it has no significant impact on Ly49H-mediated control of murine cytomegalovirus infection. Thus, while many activating NK-cell receptors are promiscuous in terms of adaptor association, our data indicate that the functional consequences of such promiscuity may vary widely and may not be evident in all cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.