ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2009
Helicobacter pylori cagA gene variants in Malaysians of different ethnicity.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- CagA toxin and risk of Helicobacter pylori-infected gastric phenotype: A meta-analysis of observational studies.PloS one · 2024Pooled it
- Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks: A meta-analysis.Medicine · 2017Pooled it
- Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal diseases in Southeast Asian countries: a meta-analysis.BMC infectious diseases · 2012Pooled it
- Article
- Review
- Genetic variation in the cag pathogenicity island of Helicobacter pylori strains detected from gastroduodenal patients in Thailand.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Fragmentation of CagA Reduces Hummingbird Phenotype Induction by Helicobactor pylori.PloS one · 2016Article
- Five year monitoring of considerable changes in tyrosine phosphorylation motifs of Helicobacter pylori cagA gene in Iran.Journal of applied genetics · 2015Article
- Five-year monitoring of considerable changes in tyrosine phosphorylation motifs of the Helicobacter pylori cagA gene in Iran.Journal of applied genetics · 2014Article
- Helicobacter pylori infection among Aborigines (the Orang Asli) in the northeastern region of Peninsular Malaysia.The American journal of tropical medicine and hygiene · 2010Article
- Clinical significance of Helicobacter pylori cagA and iceA genotype status.World journal of gastroenterology · 2010Article
- Evaluation of the anti-East Asian CagA-specific antibody for CagA phenotyping.Clinical and vaccine immunology : CVI · 2009Article
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Authors and funding
8 authors.
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Abstract
We have defined DNA repeat variability in the 3'-terminus of the cagA gene of Helicobacter pylori strains from Malaysian patients of different ethnicities. We identified different alleles based on the EPIYA repeats. cagA types A-B-D and A-B-B-D are more similar to the sequence of Japanese strains, whereas cagA types A-B-C, A-B-C-C, A-B and A-C displayed similarity to strain 26695 sequences. A significant association was found between cagA genotypes and patients' ethnicity, with cagA type A-B-D being predominantly isolated from Chinese patients and cagA type A-B-C from Malays and Indians. Our data further corroborate the possibility that variant biological activity of CagA may affect the host specificity and/or pathogenicity of H. pylori.
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