ArticleEuropean journal of applied physiology2009
WISE-2005: effect of aerobic and resistive exercises on orthostatic tolerance during 60 days bed rest in women.
Article in European journal of applied physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Effects of weightlessness on the cardiovascular system: a systematic review and meta-analysis.Frontiers in physiology · 2024Pooled it
- Haemodynamic responses to head-up tilt versus lower-body negative pressure in type 1 diabetes.Experimental physiology · 2026Trial
- Skin surface cooling improves orthostatic tolerance following prolonged head-down bed rest.Journal of applied physiology (Bethesda, Md. : 1985) · 2011Trial
- Supine cycling plus volume loading prevent cardiovascular deconditioning during bed rest.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Trial
- Comprehensive assessment of physiological responses in women during the ESA dry immersion VIVALDI microgravity simulation.Nature communications · 2023Article
- Implementation of exercise countermeasures during spaceflight and microgravity analogue studies: Developing countermeasure protocols for bedrest in older adults (BROA).Frontiers in physiology · 2022Review
- Cardiovascular deconditioning and impact of artificial gravity during 60-day head-down bed rest-Insights from 4D flow cardiac MRI.Frontiers in physiology · 2022Article
- Comparison of trunk muscle exercises in supine position during short arm centrifugation with 1 g at centre of mass and upright in 1 g.Frontiers in physiology · 2022Article
- The First Female Dry Immersion (NAIAD-2020): Design and Specifics of a 3-Day Study.Frontiers in physiology · 2021Article
- Limited Effect of 60-Days Strict Head Down Tilt Bed Rest on Vascular Aging.Frontiers in physiology · 2021Article
- MNX (Medium Duration Nutrition and Resistance-Vibration Exercise) Bed-Rest: Effect of Resistance Vibration Exercise Alone or Combined With Whey Protein Supplementation on Cardiovascular System in 21-Day Head-Down Bed Rest.Frontiers in physiology · 2020Article
- Treadmill exercise within lower body negative pressure protects leg lean tissue mass and extensor strength and endurance during bed rest.Physiological reports · 2016Article
- Treadmill exercise within lower-body negative pressure attenuates simulated spaceflight-induced reductions of balance abilities in men but not women.NPJ microgravity · 2016Article
- Artificial gravity as a countermeasure for mitigating physiological deconditioning during long-duration space missions.Frontiers in systems neuroscience · 2015Review
- Region-specific vascular remodeling and its prevention by artificial gravity in weightless environment.European journal of applied physiology · 2013Review
- Space physiology VI: exercise, artificial gravity, and countermeasure development for prolonged space flight.European journal of applied physiology · 2013Review
- Aortic, cerebral and lower limb arterial and venous response to orthostatic stress after a 60-day bedrest.European journal of applied physiology · 2012Article
- Effects of acceleration in the Gz axis on human cardiopulmonary responses to exercise.European journal of applied physiology · 2011Article
- Wasting away in Mars-Aritaville.The Journal of physiology · 2010Article
- Malnutrition and hemodynamic status in adolescents hospitalized for anorexia nervosa.Archives of pediatrics & adolescent medicine · 2010Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular deconditioning after long duration spaceflight is especially challenging in women who have a lower orthostatic tolerance (OT) compared with men. We hypothesized that an exercise prescription, combining supine aerobic treadmill exercise in a lower body negative pressure (LBNP) chamber followed by 10 min of resting LBNP, three to four times a week, and flywheel resistive training every third day would maintain orthostatic tolerance (OT) in women during a 60-day head-down-tilt bed rest (HDBR). Sixteen women were assigned to two groups (exercise, control). Pre and post HDBR OT was assessed with a tilt/LBNP test until presyncope. OT time (mean +/- SE) decreased from 17.5 +/- 1.0 min to 9.1 +/- 1.5 min (-50 +/- 6%) in control group (P < 0.001) and from 19.3 +/- 1.3 min to 13.0 +/- 1.9 min (-35 +/- 7%) in exercise group (P < 0.001), with no significant difference in OT time between the two groups after HDBR (P = 0.13). Nevertheless, compared with controls post HDBR, exercisers had a lower heart rate during supine rest (mean +/- SE, 71 +/- 3 vs. 85 +/- 4, P < 0.01), a slower increase in heart rate and a slower decrease in stroke volume over the course of tilt/LBNP test (P < 0.05). Blood volume (mean +/- SE) decreased in controls (-9 +/- 2%, P < 0.01) but was maintained in exercisers (-4 +/- 3%, P = 0.17).Our results suggest that the combined exercise countermeasure did not significantly improve OT but protected blood volume and cardiovascular response to sub tolerance levels of orthostatic stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.