ArticlePloS one2009
High differentiation among eight villages in a secluded area of Sardinia revealed by genome-wide high density SNPs analysis.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Biomarkers of aging: from molecules and surrogates to physiology and function.Physiological reviews · 2025Review
- Lack of association between common polymorphisms associated with successful aging and longevity in the population of Sardinian Blue Zone.Scientific reports · 2024Article
- Y-chromosome and Surname Analyses for Reconstructing Past Population Structures: The Sardinian Population as a Test Case.International journal of molecular sciences · 2019Article
- Genomic history of the Sardinian population.Nature genetics · 2018Article
- Article
- Overcoming the dichotomy between open and isolated populations using genomic data from a large European dataset.Scientific reports · 2017Article
- Distance-dependent patterns of molecular divergences in Tuatara mitogenomes.Scientific reports · 2015Article
- Dissecting metabolic syndrome components: data from an epidemiologic survey in a genetic isolate.SpringerPlus · 2015Article
- Geographic population structure analysis of worldwide human populations infers their biogeographical origins.Nature communications · 2014Article
- Sardinians genetic background explained by runs of homozygosity and genomic regions under positive selection.PloS one · 2014Article
- Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity.European journal of human genetics : EJHG · 2013Article
- Environmental and genetic contribution to hypertension prevalence: data from an epidemiological survey on Sardinian genetic isolates.PloS one · 2013Article
- A genome-wide analysis of populations from European Russia reveals a new pole of genetic diversity in northern Europe.PloS one · 2013Article
- Age- and sex-related variations in platelet count in Italy: a proposal of reference ranges based on 40987 subjects' data.PloS one · 2013Article
- Genome-wide scan with nearly 700,000 SNPs in two Sardinian sub-populations suggests some regions as candidate targets for positive selection.European journal of human genetics : EJHG · 2012Article
- Dissecting the genetic make-up of North-East Sardinia using a large set of haploid and autosomal markers.European journal of human genetics : EJHG · 2012Article
- Article
- Analysis of 12,517 inhabitants of a Sardinian geographic isolate reveals that predispositions to thrombocytopenia and thrombocytosis are inherited traits.Haematologica · 2011Article
- Microsatellites and SNPs linkage analysis in a Sardinian genetic isolate confirms several essential hypertension loci previously identified in different populations.BMC medical genetics · 2009Article
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14 authors.
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Abstract
To better design association studies for complex traits in isolated populations it's important to understand how history and isolation moulded the genetic features of different communities. Population isolates should not "a priori" be considered homogeneous, even if the communities are not distant and part of a small region. We studied a particular area of Sardinia called Ogliastra, characterized by the presence of several distinct villages that display different history, immigration events and population size. Cultural and geographic isolation characterized the history of these communities. We determined LD parameters in 8 villages and defined population structure through high density SNPs (about 360 K) on 360 unrelated people (45 selected samples from each village). These isolates showed differences in LD values and LD map length. Five of these villages show high LD values probably due to their reduced population size and extreme isolation. High genetic differentiation among villages was detected. Moreover population structure analysis revealed a high correlation between genetic and geographic distances. Our study indicates that history, geography and biodemography have influenced the genetic features of Ogliastra communities producing differences in LD and population structure. All these data demonstrate that we can consider each village an isolate with specific characteristics. We suggest that, in order to optimize the study design of complex traits, a thorough characterization of genetic features is useful to identify the presence of sub-populations and stratification within genetic isolates.
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