ArticleMolecular vision2009
Relationship between the expression of cyclooxygenase-2 and survivin in primary pterygium.
Article in Molecular vision, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- EFFECT OF SUN EXPOSURE DURATION ON CYCLOOXYGENASE-2 EXPRESSION IN THE CONJUNCTIVA.Acta clinica Croatica · 2019Article
- Immunophenotypic characterization of telocyte-like cells in pterygium.Molecular vision · 2018Article
- Vitamin D and vitamin D receptor in patients with ophthalmic pterygium.European journal of histochemistry : EJH · 2017Article
- Aberrant expression of genes and proteins in pterygium and their implications in the pathogenesis.International journal of ophthalmology · 2017Review
- MicroRNA-215 Regulates Fibroblast Function: Insights from a Human Fibrotic Disease.Cell cycle (Georgetown, Tex.) · 2015Article
- Induction of endothelial RAGE expression in pterygium.Molecular vision · 2014Article
- Survivin and p53 expression in primary and recurrent pterygium in Chinese patients.International journal of ophthalmology · 2011Article
- Cyclooxygenase-2-expressing macrophages in human pterygium co-express vascular endothelial growth factor.Molecular vision · 2011Article
- Inhibition of cyclooxygenase-2-dependent survivin mediates decursin-induced apoptosis in human KBM-5 myeloid leukemia cells.Cancer letters · 2010Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the expression of cyclooxygenase-2 (COX-2) in a group of 93 Ecuadorian primary pterygia and to evaluate a possible association between COX-2 and survivin.
methodsPrimary pterygium samples were treated for the immunohistochemical evaluation of COX-2 and survivin. Mouse monoclonal antibody to COX-2 and rabbit polyclonal antibody to survivin were used. Statistical analysis was performed using the SPSS statistical software package, version 15.0.
resultsIn our study, 63 (67.7%) primary pterygia samples were positive for COX-2 staining, and 70 (75.3%) specimens were positive for survivin expression. In the group of pterygia with survivin immunostaining, there were 55 (78.6%) samples with COX-2 expression. The staining of both COX-2 and survivin was localized in the lower and middle layers of the epithelium. When analyzed by Fisher's exact test, the expression of COX-2 showed a strong significant correlation with survivin (p=0.0002).
conclusionsThese data, showing a significant correlation between COX-2 and survivin in primary pterygium, suggest that pterygium may originate through an anti-apoptotic mechanism.
Indexed as
Identifiers
19247455PMC2647970W1495929737What OpenQuestion holds
Registered trials
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