ArticleMolecular biology and evolution2009
Evolutionary origin and genomic organization of micro-RNA genes in immunoglobulin lambda variable region gene family.
Article in Molecular biology and evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Functions and underlying mechanisms of miR-650 in human cancers.Cancer cell international · 2022Review
- Stage-Specific Non-Coding RNA Expression Patterns during In Vitro Human B Cell Differentiation into Antibody Secreting Plasma Cells.Non-coding RNA · 2022Article
- Characterization of Lamprey BAFF-like Gene: Evolutionary Implications.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- MicroRNA-650 in a copy number-variable region regulates the production of interleukin 6 in human osteosarcoma cells.Oncology letters · 2015Article
- Organization of lamprey variable lymphocyte receptor C locus and repertoire development.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Evolutionary genomics of immunoglobulin-encoding Loci in vertebrates.Current genomics · 2012Article
- Probing Evolutionary Biography of MicroRNAs and Associated Factors.Current genomics · 2012Article
- Co-expression of host and viral microRNAs in porcine dendritic cells infected by the pseudorabies virus.PloS one · 2011Article
- Comparative genomics and evolution of the alpha-defensin multigene family in primates.Molecular biology and evolution · 2010Article
- MicroRNA 125b inhibition of B cell differentiation in germinal centers.International immunology · 2010Article
- Reply to evolutionary flux of canonical microRNAs and mirtrons in Drosophila.Nature genetics · 2010Article
- miRTRAP, a computational method for the systematic identification of miRNAs from high throughput sequencing data.Genome biology · 2010Article
- Analysis of the immunoglobulin light chain genes in zebra finch: evolutionary implications.Molecular biology and evolution · 2010Article
- An overview of the introns-first theory.Journal of molecular evolution · 2009Article
- Genomic organization and evolution of immunoglobulin kappa gene enhancers and kappa deleting element in mammals.Molecular immunology · 2009Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The genomic organizations and functions of many miRNA genes have been described in recent years, but the origin and evolution of miRNAs in the exons of protein-coding genes are not well understood. The overlap of miR-650 genes with the protein-coding region of immunoglobulin lambda variable (IGVL) region genes has given a unique opportunity to witness a birth of miRNA gene. Both sequence comparisons and structure predictions indicate that the miR-650 genes are present in multiple copies and overlap in the same transcription orientation with the leader exon of primate IGVL genes of a specific phylogenetic clan (clan II). By reconstructing the phylogeny of the clan II IGVL genes, the stages in which the mutations accumulated in the leader exon and gave rise to a stable hairpin structure of miR-650 could be documented. The copy number variation of miR-650 genes among different species is the result of the duplication or deletion of the IGVL genes. To my knowledge, this is the first report of a genomic association between miRNA and the protein-coding genes of a multigene family. Analysis of the upstream region of the leader exon suggests that the IGVL and the mir-650 genes use the same promoter region for their transcription. However, in contrast to the general expectation about the expression of miRNAs that overlap with other genes in the same transcriptional orientation, this analysis provides evidence that the miR-650 gene is apparently transcribed independently of the IGVL gene with which it overlaps because they are expressed in different cell types.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.