Evidence map›Paper›PMID 19246575›Full record

ArticleDiabetes care2009

Diabetes in non-Hispanic white youth: prevalence, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study.

Ronny A Bell, Elizabeth J Mayer-Davis, Jennifer W Beyer, Ralph B D'Agostino, Jean M Lawrence, Barbara Linder, Lenna L Liu, Santica M Marcovina, Beatriz L Rodriguez, Desmond Williams and 2 more

2 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in Diabetes care, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 95 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 8 pooled it
12.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03926598 completednot on this mapstarted 2019, after this paper: background citation

User Evaluation of the Guide To Goals Application - a Care Coordination Tool to Translate ADA Clinical Standards of Care for Children With T2D Into Practice

TypeobservationalSponsorGeorgia Institute of TechnologyRan2019 to 2019Enrolled6ConditionsType2 Diabetes MellitusArmsPatient and/or Family Member Intervention, Certified Diabetes Educator Intervention, Physician Intervention, Front Desk Staff Intervention, Nurse Intervention
NCT06837181 recruitingnot on this mapstarted 2025, after this paper: background citation

Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

TypeobservationalSponsorJaeb Center for Health ResearchRan2025 to 2028Enrolled200ConditionsCystic Fibrosis (CF), Cystic Fibrosis-related Diabetes, Diabetes, RetinopathyArmsobservational study
3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 8 syntheses or guidelines pooled it, 207 citations in OpenAlex.

  1. Pooled it
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  7. Overweight and obesity in youth with type 1 diabetes.Annual review of nursing research · 2013
    Pooled it
  8. Guideline
  9. Trial
  10. Factors Associated with Higher Pro-Inflammatory Tumor Necrosis Factor-α Levels in Young Women with Type 1 Diabetes.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association · 2016
    Trial
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35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 1 country.

Ronny A BellDivision of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. rbell@wfubmc.edu
Elizabeth J Mayer-Davis
Jennifer W Beyer
Ralph B D'Agostino
Jean M Lawrence
Barbara Linder
Lenna L Liu
Santica M Marcovina
Beatriz L Rodriguez
Desmond Williams
Dana Dabelea
SEARCH for Diabetes in Youth Study Group
Wake Forest University · USUniversity of Washington · USCenters for Disease Control and Prevention · USKaiser Permanente · USNational Institute of Diabetes and Digestive and Kidney Diseases · USPacific Health Research and Education Institute · USUniversity of Colorado Health · USUniversity of South Carolina · US

Funding

ZIPRASIDONE IN NORMAL HEPATIC FUNCTION SUBJECTS &IN HEPATIC DYSFUCTIN SUBJECTSM01RR000037 · NCRR · UNIVERSITY OF WASHINGTON · PI GIBSON, RONALD L · 1985 to 2007
$33.8M
ZIDOVUDINE &LAMIVUDINE &NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFM01RR001271 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$22.7M
ZORVIRAX ORAL SUSPENSION FOR SEVERE CHILDHOOD HERPES VIRUS INFECTIONSM01RR000069 · NCRR · UNIVERSITY OF COLORADO DENVER · PI KRUGMAN, RICHARD D. · 1985 to 2008
$22.1M
VITAMIN K DEFICIENCY IN CHOLESTATIC LIVER DISEASEM01RR008084 · NCRR · CINCINNATI CHILDRENS HOSP MED CTR · PI STRAUSS, ARNOLD W · 1994 to 2009
$20.6M
ZINC AND COPPER METABOLISM IN COLLAGEN DISORDERSM01RR001070 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI REVES, JOSEPH G · 1985 to 2009
$16.3M
SEARCH for Diabetes in Youth Coordinating CenterU01DP000250 · DP · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BELL, RONNY A · 2005 to 2009
$4.8M
SEARCH for Diabetes in Youth 2: Colorado CenterU01DP000247 · DP · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 2005 to 2009
$3.6M
SEARCH for Diabetes in Youth 2: South Carolina CenterU01DP000254 · DP · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAYER-DAVIS, ELIZABETH J · 2005 to 2009
$3.5M
SEARCH for Diabetes in Youth 2: California CenterU01DP000246 · DP · KAISER FOUNDATION RESEARCH INSTITUTE · PI LAWRENCE, JEAN MARIE · 2005 to 2009
$2.8M
SEARCH for Diabetes in Youth 2: Washington SiteU01DP000244 · DP · SEATTLE CHILDREN'S HOSPITAL · PI PIHOKER, CATHERINE · 2005 to 2009
$2.7M
SEARCH for Diabetes in Youth 2: Ohio CenterU01DP000248 · DP · CINCINNATI CHILDRENS HOSP MED CTR · PI DOLAN, LAWRENCE M · 2005 to 2009
$2.7M
SEARCH for Diabetes in Youth 2: Hawaii CenterU01DP000245 · DP · PACIFIC HEALTH RESEARCH INSTITUTE · PI RODRIGUEZ, BEATRIZ L. · 2005 to 2009
$2.4M
NCCDPHP CDC HHS DP-05-069NCCDPHP CDC HHS U01 DP000244NCCDPHP CDC HHS U01 DP000245NCCDPHP CDC HHS U01 DP000246NCCDPHP CDC HHS U01 DP000247NCCDPHP CDC HHS U01 DP000248NCCDPHP CDC HHS U01 DP000250NCCDPHP CDC HHS U01 DP000254NCRR NIH HHS M01 RR000037NCRR NIH HHS M01 RR000069NCRR NIH HHS M01RR00037NCRR NIH HHS M01 RR00069NCRR NIH HHS M01 RR001070NCRR NIH HHS M01 RR001271NCRR NIH HHS M01RR001271NCRR NIH HHS M01 RR008084NCRR NIH HHS M01 RR01070NCRR NIH HHS M01 RR08084PHS HHS PA 00097
6 · The paper itself

Abstract

objectiveTo investigate the incidence, prevalence, and clinical characteristics of diabetes among U.S. non-Hispanic white (NHW) youth. RESEARCH DESIGN AND

methodsData from the SEARCH for Diabetes in Youth Study (SEARCH study), a multicenter study of diabetes among youth aged 0-19 years, were examined. Incidence rates were calculated per 100,000 person-years across 4 incident years (2002-2005), and prevalence in 2001 was calculated per 1,000 youths. Information obtained by questionnaire, physical examination, and blood and urine collection was analyzed to describe the characteristics of youth who completed an in-person visit.

resultsThe prevalence of type 1 diabetes (at ages 0-19 years) was 2.00/1,000, which was similar for male (2.02/1,000) and female (1.97/1,000) subjects. The incidence of type 1 diabetes was 23.6/100,000, slightly higher for male compared with female subjects (24.5 vs. 22.7 per 100,000, respectively, P = 0.04). Incidence rates of type 1 diabetes among youth aged 0-14 years in the SEARCH study are higher than all previously reported U.S. studies and many European studies. Few cases of type 2 diabetes in youth aged <10 years were found. The prevalence of type 2 diabetes (at ages 10-19 years) was 0.18/1,000, which is significantly higher for female compared with male subjects (0.22 vs. 0.15 per 1,000, P = 0.01). Incidence of type 2 diabetes was 3.7/100,000, with similar rates for female and male subjects (3.9 vs. 3.4 per 1,000, respectively, P = 0.3). High levels of abnormal cardiometabolic and behavioral risk factor profiles were common among youth with both type 1 and type 2 diabetes. For example, within each of four age-groups for youth with type 1 diabetes and two age-groups for youth with type 2 diabetes, >40% had elevated LDL cholesterol, and <3% of youth aged >10 years met current recommendations for intake of saturated fat. Among youth aged >or=15 years, 18% with type 1 and 26% with type 2 diabetes were current smokers.

conclusionsThe SEARCH study is one of the most comprehensive studies of diabetes in NHW youth. The incidence of type 1 diabetes in NHW youth in the U.S. is one of the highest in the world. While type 2 diabetes is still relatively rare, rates are several-fold higher than those reported by European countries. We believe efforts directed at improving the cardiometabolic and behavioral risk factor profiles in this population are warranted.

Indexed as

AdolescentChildChild, PreschoolDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansInfantInfant, NewbornMalePrevalenceSocioeconomic FactorsUnited StatesWhite PeopleYoung Adult

Identifiers

PMID19246575
PMCPMC2647694
OpenAlexW2164396925

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.