ArticleAJNR. American journal of neuroradiology2009
Diffusion abnormalities and reduced volume of the ventral cingulum bundle in agenesis of the corpus callosum: a 3T imaging study.
Article in AJNR. American journal of neuroradiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00305305 (Disorders of Cerebral Development), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Disorders of Cerebral Development: A Phenotypic and Genetic Analysis
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- White matter microstructure in fetal alcohol spectrum disorders: A systematic review of diffusion tensor imaging studies.Human brain mapping · 2019Pooled it
- The role of corpus callosum development in functional connectivity and cognitive processing.PloS one · 2012Trial
- Dandy-Walker Malformation in a Girl withMolecular syndromology · 2023Article
- Effect of corpus callosum agenesis on the language network in children and adolescents.Brain structure & function · 2021Article
- Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development.Neuron · 2020Article
- Integration Between Cerebral Hemispheres Contributes to Defense Mechanisms.Frontiers in psychology · 2020Article
- White Matter Dissection of the Fetal Brain.Frontiers in neuroanatomy · 2020Article
- Underdevelopment of the Human Hippocampus in Callosal Agenesis: An In Vivo Fetal MRI Study.AJNR. American journal of neuroradiology · 2019Article
- Quantitative brain morphological analysis in CHARGE syndrome.NeuroImage. Clinical · 2019Article
- Sonographic Development of the Pericallosal Vascularization in the First and Early Second Trimester of Pregnancy.AJNR. American journal of neuroradiology · 2018Article
- Heritability of the limbic networks.Social cognitive and affective neuroscience · 2016Article
- Review of diffusion tensor imaging and its application in children.Pediatric radiology · 2015Review
- Clinical, genetic and imaging findings identify new causes for corpus callosum development syndromes.Brain : a journal of neurology · 2014Review
- Article
- Both rare and de novo copy number variants are prevalent in agenesis of the corpus callosum but not in cerebellar hypoplasia or polymicrogyria.PLoS genetics · 2013Article
- Diffusion tensor imaging and fiber tractography in brain malformations.Pediatric radiology · 2013Review
- Article
- Resting-state networks and the functional connectome of the human brain in agenesis of the corpus callosum.Brain connectivity · 2013Article
- Processing speed delays contribute to executive function deficits in individuals with agenesis of the corpus callosum.Journal of the International Neuropsychological Society : JINS · 2012Article
- Complete corpus callosum agenesis: can it be mild?Case reports in pediatrics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
background and purposePatients with agenesis of the corpus callosum (AgCC) exhibit cognitive and behavioral impairments that are not replicated by surgical transection of the callosum, suggesting that other anatomic changes may contribute to the observed clinical findings. The purpose of this study was to determine whether the ventral cingulum bundle (VCB) is affected in patients with AgCC by using diffusion tensor imaging (DTI) and volumetry. MATERIALS AND
methodsTwelve participants with AgCC (8 males and 4 females; mean age, 30 +/- 20) and 12 control subjects matched for age and sex (mean age, 37 +/- 19) underwent MR imaging and DTI at 3T. 3D fiber tracking of the VCB was generated from DTI and the average fractional anisotropy (FA) was computed for the tracked fibers. Additionally, the volume, cross-sectional area, and length of the VCB were measured by manually drawn regions of interest on thin-section coronal T1-weighted images. The Student t test was used to compare these results.
resultsCompared with controls, subjects with AgCC demonstrated significantly reduced FA in the right VCB (P = .0098) and reduced volume and cross-sectional areas of both the left and right VCB (P < .001 for all metrics). The length of the VCB was also significantly reduced in the complete AgCC subgroup compared with controls (P = .030 in the right and P = .046 in the left, respectively).
conclusionsPatients with AgCC have abnormal microstructure and reduced volume of the VCB, suggesting that abnormalities in intrahemispheric white matter tracts may be an important contributor to the clinical syndrome in patients with AgCC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.